Noninvasive monitoring of orthotopic glioblastoma therapy response using RGD-conjugated iron oxide nanoparticles.

Biomaterials
Fan ZhangXiaoyuan Chen

Abstract

Noninvasive imaging techniques have been considered important strategies in the clinic to monitor tumor early response to therapy. In the present study, we applied RGD peptides conjugated to iron oxide nanoparticles (IONP-RGD) as contrast agents in magnetic resonance imaging (MRI) to noninvasively monitor the response of a vascular disrupting agent VEGF(121)/rGel in an orthotopic glioblastoma model. RGD peptides were firstly coupled to IONPs coated with a crosslinked PEGylated amphiphilic triblock copolymer. In vitro binding assays confirmed that cellular uptake of particles was mainly dependent on the interaction between RGD and integrin α(v)β(3) of human umbilical vein endothelial cells (HUVEC). The tumor targeting of IONP-RGD was observed in an orthotopic U87 glioblastoma model. Finally, noninvasive monitoring of the tumor response to VEGF(121)/rGel therapy at early stages of treatment was successfully accomplished using IONP-RGD as a contrast agent for MRI, a superior method over common anatomical approaches which are based on tumor size measurements. This preclinical study can accelerate anticancer drug development and promote clinical translation of nanoprobes.

References

May 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B R RosenT J Brady
Jun 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Liesbeth M VeenendaalMichael G Rosenblum
Oct 19, 2004·Chemical Communications : Chem Comm·William W YuVicki L Colvin
Nov 30, 2004·Nature Materials·Jongnam ParkTaeghwan Hyeon
Jun 22, 2005·Neoplasia : an International Journal for Oncology Research·Sophia RanMichael G Rosenblum
Oct 21, 2006·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Andrew R HsuXiaoyuan Chen
Jan 16, 2007·Journal of Biotechnology·Sehoon KimMichael G Rosenblum
Feb 26, 2008·Nature Medicine·Zhaozhong HanDennis E Hallahan
Apr 22, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Wolfgang A Weber
Aug 22, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Xinglu HuangJun Ren
Dec 15, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Adrianus J de LangenOtto S Hoekstra
May 7, 2011·Theranostics·Yunpeng Ye, Xiaoyuan Chen
May 28, 2011·Biomaterials·Virendra Gajbhiye, Narendra K Jain
Nov 9, 2011·Nature Medicine·Sara M Weis, David A Cheresh

❮ Previous
Next ❯

Citations

Nov 5, 2013·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Gwang Tae NohJeong Kon Kim
Sep 26, 2013·Advanced Drug Delivery Reviews·Yu ChengMaciej S Lesniak
Mar 7, 2014·Pharmaceutical Research·Dan WangHua Ai
Apr 11, 2013·Expert Review of Molecular Diagnostics·Tae Hyung KimXiaoyuan Chen
Apr 29, 2014·Expert Opinion on Drug Delivery·Michelle L WegscheidMaciej S Lesniak
Sep 3, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Nathalie SchleichVéronique Préat
Jan 23, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Fatemeh PourgholiMehdi Yousefi
Aug 18, 2012·Biochemical and Biophysical Research Communications·Fan ZhangXiaoyuan Chen
Oct 30, 2015·Colloids and Surfaces. B, Biointerfaces·Hongyan XuDongmei Xu
Jun 10, 2015·Chemical Society Reviews·Qianjun HeXiaoyuan Chen
Jul 6, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Behdokht BahramiMohammad Hojjat-Farsangi
Nov 18, 2016·BioImpacts : BI·Saeideh SameYadollah Omidi
Jan 18, 2018·Brain Sciences·Mayra PaolilloSergio Schinelli
Mar 3, 2018·Chemical Society Reviews·Pengcheng ZhangHonggang Cui
May 19, 2018·Organic & Biomolecular Chemistry·Fabien ThoreauDidier Boturyn
Oct 11, 2017·Advanced Healthcare Materials·Jalal MosayebiSophie Laurent
Aug 4, 2018·Therapeutic Delivery·Puja S Gaikwad, Rinti Banerjee
May 16, 2019·Chemical Society Reviews·Wei TangXiaoyuan Chen
Feb 2, 2017·Beilstein Journal of Nanotechnology·Oihane K ArriortuaJosé Javier Echevarria-Uraga
May 20, 2015·Science and Technology of Advanced Materials·Wataru KawamuraKazunori Kataoka
Nov 4, 2017·Contrast Media & Molecular Imaging·Ying-Yu MaXiao-Zhou Mou
Jun 30, 2019·Current Medicinal Chemistry·Mehdi RajabiShaker A Mousa
Sep 5, 2020·Journal of Nanobiotechnology·Jinyeong ChoiHyung-Jun Im
Jun 14, 2015·Journal of Neuro-oncology·Nolan Ung, Isaac Yang
Dec 7, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Huihui WangMingqian Tan
May 4, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Dominie L MiyasatoCristina Zavaleta
May 5, 2021·Journal of Nanobiotechnology·Wei ZhaoLigong Lu
Jul 9, 2013·Molecular Pharmaceutics·Amit GangarCarston R Wagner
Aug 3, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Vinith YathindranathTorsten Hegmann
Dec 7, 2019·ACS Applied Materials & Interfaces·Renuka KhatikQing Yang
Apr 11, 2018·ACS Central Science·Dokyoon KimTaeghwan Hyeon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Tumorigenesis

Breast tumorigenesis involves the production or formation of tumor(s) in breast tissue. Discover the latest research on breast tumorigenesis here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.