Noninvasive prenatal diagnosis: 2010

Clinics in Laboratory Medicine
Mark I Evans, Michael Kilpatrick

Abstract

Looking for fetal cells and now nucleic acids has been the holy grail of prenatal diagnosis for more than a century. The use of noninvasive diagnostics has potential far beyond aneuploidy; in fact, its use for Rhesus disease is already commonplace in Europe. Accurate segregation of fetal cells from maternal cells or identification of cell-free fetal (cff) DNA or RNA is critical to the development of fetal cells as a screening or diagnostic prenatal technique. The large number of approaches that have been used is testimony to the fact that none of them have been particularly successful. This article discusses the current status and challenges of noninvasive prenatal diagnosis.

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Citations

Oct 27, 2011·Prenatal Diagnosis·Reana TischlerKelly E Ormond
Dec 18, 2014·International Journal of Molecular Medicine·Barbora KonečnáPeter Celec
Nov 14, 2012·Laboratory Investigation; a Journal of Technical Methods and Pathology·Chise TatenoKatsutoshi Yoshizato
Oct 18, 2012·Clinical Chemistry and Laboratory Medicine : CCLM·Rossa Wai Kwun Chiu, Yuk Ming Dennis Lo

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