Noninvasive quantification of the differential portal and arterial contribution to the liver blood supply from PET measurements using the 11C-acetate kinetic model

IEEE Transactions on Bio-medical Engineering
Sirong Chen, Dagan Feng

Abstract

Our recent research has demonstrated that 11C-acetate could be a complementary tracer to 18F-fluorodeoxyglucose (FDG) in positron emission tomography (PET) imaging of hepatocellular carcinoma (HCC). In our previous modeling study, a three-compartment four-parameter model with a fixed contribution ratio of the liver's two blood supplies was proposed to characterize the kinetic behavior of 11C-acetate in liver. However, in real pathology, both tumor and nontumor liver tissue can be heterogeneous in the distribution and proportion of the two blood supplies. To further improve the accuracy of quantitative analysis, the actual proportion of the hepatic artery and portal vein (PV) in different regions of interest (ROIs) was investigated in this study. An extra parameter av was included in the model input function to describe the contribution of PV to the liver. Ten ROIs extracted from six patients were used to test the models with fixed/nonfixed weighted dual-input function. The weighted nonlinear least squares algorithm was used to estimate all of the parameters. Evaluation of the adequacy of the two models was conducted and the computer simulation was performed to test the estimation accuracy of the new model. The forward clearance...Continue Reading

References

Sep 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W W Lautt, C V Greenway
Mar 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C S PatlakJ D Fenstermacher
Apr 16, 2004·IEEE Transactions on Medical Imaging·Sirong ChenZheru Chi

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Citations

Dec 18, 2013·Medical Engineering & Physics·Huiting QiaoDeyu Li
May 12, 2006·IEEE Transactions on Bio-medical Engineering·Sirong Chen, Dagan Feng
Dec 27, 2005·Computer Methods and Programs in Biomedicine·Hon-Chit ChoiKoon-Pong Wong

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