PMID: 7978550May 1, 1994

Noninvasive recovery of acinar anatomic information from CO2 expirograms

Annals of Biomedical Engineering
J D SchwardtP W Scherer

Abstract

A numerical single path model of respiratory gas exchange with distributed alveolar gas sources was used to estimate the anatomical changes in small peripheral airways such as occur in chronic obstructive pulmonary diseases (COPD). A previous sensitivity analysis of the single path model showed that decreasing total acinar airway cross-sectional area by an area reduction factor, R, results in computed gas expirograms with Phase III steepening similar to that observed in COPD patients. From experimental steady state CO2 washout data recorded from six healthy subjects and six COPD patients, optimized area reduction factors for the single path model were found that characterize peripheral airway anatomy for each subject. Area reduction factors were then combined with measured functional residual capacity data to calculate the normalized peripheral airspace diameters in a given subject, relative to the airspace diameters in the generations of an idealized standard lung. Mean area reduction factors for the patient subgroup were 63% of those for the healthy subgroup, which is related to the gas transport limitation observed in disease. Mean airspace sizes for the patient subgroup were 235% of the healthy subgroup, which characterizes...Continue Reading

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Citations

Aug 18, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Gerardo TusmanElsio Turchetto
Jan 1, 1996·Respiration Physiology·P W SchererG R Neufeld
Jul 23, 2003·Respiratory Physiology & Neurobiology·J P WhiteleyC E W Hahn
Jul 1, 1997·American Journal of Respiratory and Critical Care Medicine·K YamaguchiE Koda
Jun 12, 2009·Journal of Clinical Monitoring and Computing·Gerardo TusmanFernando Clara
Oct 26, 2005·Toxicology and Applied Pharmacology·Adekemi TaylorJames S Ultman
Oct 1, 2005·Inhalation Toxicology·Wade H ReeserAbdellaziz Ben-Jebria
May 3, 2014·Current Opinion in Critical Care·Fernando Suarez-SipmannGerardo Tusman
Aug 15, 2019·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Mônica Corso PereiraRosemeri Maurici
Aug 15, 2018·Frontiers in Physiology·Ramin GhorbaniFlorian M Schmidt
Apr 2, 2005·Journal of Applied Physiology·G TusmanS H Böhm

Related Concepts

Carbon Dioxide
In Silico
Computer Assisted Diagnosis
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Lung Diseases, Obstructive
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Pulmonary Gas Exchange

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