Noninvasive Relative Quantification of [11 C]ABP688 PET Imaging in Mice Versus an Input Function Measured Over an Arteriovenous Shunt

Frontiers in Neurology
Jeroen VerhaegheSteven Staelens

Abstract

Impairment of the metabotropic glutamate receptor 5 (mGluR5) has been implicated with various neurologic disorders. Although mGluR5 density can be quantified with the PET radiotracer [11C]ABP688, the methods for reproducible quantification of [11C]ABP688 PET imaging in mice have not been thoroughly investigated yet. Thus, this study aimed to assess and validate cerebellum as reference region for simplified reference tissue model (SRTM), investigate the feasibility of a noninvasive cardiac image-derived input function (IDIF) for relative quantification, to validate the use of a PET template instead of an MRI template for spatial normalization, and to determine the reproducibility and within-subject variability of [11C]ABP688 PET imaging in mice. Blocking with the mGluR5 antagonist MPEP resulted in a reduction of [11C]ABP688 binding of 41% in striatum (p < 0.0001), while no significant effect could be found in cerebellum (-4.8%, p > 0.99) indicating cerebellum as suitable reference region for mice. DVR-1 calculated using a noninvasive IDIF and an arteriovenous input function correlated significantly when considering the cerebellum as the reference region (striatum: DVR-1, r = 0.978, p < 0.0001). Additionally, strong correlations ...Continue Reading

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Citations

Jul 17, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Daniele BertoglioSteven Staelens
Dec 4, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Daniele BertoglioSteven Staelens
Mar 27, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Catriona WimberleyIrène Buvat
May 26, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Daniele BertoglioSteven Staelens
Oct 16, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Daniele BertoglioSteven Staelens
Feb 3, 2022·Science Translational Medicine·Daniele BertoglioIgnacio Munoz-Sanjuan

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