Noninvasive Staging of Kidney Dysfunction Enabled by Renal-Clearable Luminescent Gold Nanoparticles

Angewandte Chemie
Mengxiao YuJie Zheng

Abstract

As a "silent killer", kidney disease is often hardly detected at an early stage but can cause lethal kidney failure later on. Thus, a preclinical imaging technique that can readily differentiate between the stages of kidney dysfunction is highly desired for improving our fundamental understanding of kidney disease progression. Herein, we report that in vivo fluorescence imaging, enabled by renal-clearable near-infrared-emitting gold nanoparticles, can noninvasively detect kidney dysfunction, report on the dysfunctional stages, and even reveal adaptive function in a mouse model of unilateral obstructive nephropathy, which cannot be diagnosed with routine kidney function markers. These results demonstrate that low-cost fluorescence kidney functional imaging is highly sensitive and useful for the longitudinal, noninvasive monitoring of kidney dysfunction progression in preclinical research.

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Citations

May 10, 2017·Biomaterials Science·Lingshan GongJinbin Liu
Jun 6, 2017·Nano Letters·Yang ZhaoGang Han
Jun 7, 2018·Nanoscale·Xi KangManzhou Zhu
Sep 25, 2018·Chembiochem : a European Journal of Chemical Biology·Yawei MiaoHailin Cong
Sep 6, 2018·Angewandte Chemie·Mengxiao YuJie Zheng
Jun 19, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Xinyue DouJianping Xie
Sep 4, 2019·Nature Nanotechnology·Colleen N LoynachanMolly M Stevens
Feb 27, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Estelle PorretJean-Luc Coll
Oct 3, 2019·Advanced Materials·Haile LiuXiao-Dong Zhang
Aug 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Guohai LiangDa Xing
Jun 28, 2016·Angewandte Chemie·Jinbin LiuJie Zheng
Jan 11, 2017·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Jing XuJie Zheng
Nov 21, 2017·Advanced Functional Materials·Liang ChengWeibo Cai
Aug 5, 2020·Journal of Nanobiotechnology·Xiaoying WangZongyu Xie
Aug 11, 2017·ChemistryOpen·Jiaguo Huang, Norbert Gretz
May 18, 2021·Nano Letters·Qian ChenZhilei Ge
Jun 15, 2021·Chemical Science·Yuxiang ChenRongchao Jin
Aug 14, 2020·Accounts of Chemical Research·Dawei JiangWeibo Cai
Nov 7, 2018·Accounts of Chemical Research·Belén Nieto-Ortega, Thomas Bürgi
May 1, 2020·Bioconjugate Chemistry·Xingya JiangJie Zheng
Sep 8, 2021·Journal of Nanobiotechnology·Dong-Yang ZhangPeng Huang

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