Noninvasive wave intensity analysis predicts functional worsening in children with pulmonary arterial hypertension

American Journal of Physiology. Heart and Circulatory Physiology
Michal SchäferUyen Truong

Abstract

The purpose of the present study was to characterize pulmonary vascular stiffness using wave intensity analysis (WIA) in children with pulmonary arterial hypertension (PAH), compare the WIA indexes with catheterization- and MRI-derived hemodynamics, and assess the prognostic ability of WIA-derived biomarkers to predict the functional worsening. WIA was performed in children with PAH ( n = 40) and healthy control subjects ( n = 15) from phase-contrast MRI-derived flow and area waveforms in the main pulmonary artery (MPA). From comprehensive WIA spectra, we collected and compared with healthy control subjects forward compression waves (FCW), backward compression waves (BCW), forward decompression waves (FDW), and wave propagation speed ( c-MPA). There was no difference in the magnitude of FCW between PAH and control groups (88 vs. 108 mm5·s-1·ml-1, P = 0.239). The magnitude of BCW was increased in patients with PAH (32 vs. 5 mm5·s-1·ml-1, P < 0.001). There was no difference in magnitude of indexed FDW (32 vs. 28 mm5·s-1·ml-1, P = 0.856). c-MPA was increased in patients with PAH (3.2 vs. 1.6 m/s, P < 0.001). BCW and FCW correlated with mean pulmonary arterial pressure, right ventricular volumes, and ejection fraction. Elevated ind...Continue Reading

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Citations

Dec 14, 2018·The European Respiratory Journal·Erika B RosenzweigRolf M F Berger
Sep 21, 2019·American Journal of Respiratory and Critical Care Medicine·Paul J CritserJason C Woods
Dec 21, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Benjamin S FrankJohannes C von Alvensleben
Mar 14, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Michal SchäferMichael V Di Maria
Jul 12, 2020·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Ryan M ReavettePeter D Weinberg
Jul 24, 2020·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Paul J CritserJason C Woods
Nov 20, 2020·Pediatric Pulmonology·Ernestina MelicoffChristian Benden
Jun 5, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Michal SchäferMichael E Yeager
Jun 19, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Mitchel J ColebankMette S Olufsen
Aug 6, 2021·Journal of Magnetic Resonance Imaging : JMRI·Laura C SaundersJim M Wild

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Methods Mentioned

BETA
sedation

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MATLAB
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