Nonlinear analysis of electroencephalogram at rest and during cognitive tasks in patients with schizophrenia.

Journal of Psychiatry & Neuroscience : JPN
Elisa CarlinoPaola Rocca

Abstract

In spite of the large number of studies on schizophrenia, a full understanding of its core pathology still eludes us. The application of the nonlinear theory of electroencephalography (EEG) analysis provides an interesting tool to differentiate between physiologic conditions (e.g., resting state and mathematical task) and normal and pathologic brain activities. The aim of the present study was to investigate nonlinear EEG activity in patients with schizophrenia. We recorded 19-lead EEGs in patients with stable schizophrenia and healthy controls under 4 different conditions: eyes closed, eyes open, forward counting and backward counting. A nonlinear measure of complexity was calculated by means of correlation dimension (D2). We included 17 patients and 17 controls in our analysis. Comparing the 2 populations, we observed greater D2 values in the patient group. In controls, increased D2 values were observed during active states (eyes open and the 2 cognitive tasks) compared with baseline conditions. This increase of brain complexity, which can be interpreted as an increase of information processing and integration, was not preserved in the patient population. Patients with schizophrenia were taking antipsychotic medications, so t...Continue Reading

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Citations

Aug 5, 2015·Neuroscience Letters·Elisa CarlinoPaola Rocca
Nov 22, 2013·Journal of Psychopharmacology·Joel Frohlich, John D Van Horn
Mar 1, 2018·Frontiers in Human Neuroscience·Nan QiuDezhong Yao
Sep 25, 2018·Frontiers in Physiology·Antonio J Ibáñez-MolinaM T Bajo
Jul 4, 2019·Chaos·R A Thuraisingham
Mar 23, 2018·Cognitive Neurodynamics·T Nimmy JohnRamshekhar Menon
Dec 12, 2020·Schizophrenia Bulletin·Georg Northoff, Javier Gomez-Pilar

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