Nonlinear-dynamical arrhythmia control in humans

Proceedings of the National Academy of Sciences of the United States of America
David J ChristiniBruce B. Lerman

Abstract

Nonlinear-dynamical control techniques, also known as chaos control, have been used with great success to control a wide range of physical systems. Such techniques have been used to control the behavior of in vitro excitable biological tissue, suggesting their potential for clinical utility. However, the feasibility of using such techniques to control physiological processes has not been demonstrated in humans. Here we show that nonlinear-dynamical control can modulate human cardiac electrophysiological dynamics by rapidly stabilizing an unstable target rhythm. Specifically, in 52/54 control attempts in five patients, we successfully terminated pacing-induced period-2 atrioventricular-nodal conduction alternans by stabilizing the underlying unstable steady-state conduction. This proof-of-concept demonstration shows that nonlinear-dynamical control techniques are clinically feasible and provides a foundation for developing such techniques for more complex forms of clinical arrhythmia.

References

Aug 28, 1992·Science·A GarfinkelJ N Weiss
Jan 1, 1992·Biological cybernetics·F Ravelli, R Antolini
Oct 1, 1990·Circulation Research·D T Kaplan, R J Cohen
Jan 1, 1988·Circulation·J M SmithR J Cohen
Nov 1, 1969·The Journal of Clinical Investigation·A D Jose, R R Taylor
Nov 17, 1995·Science·R A GrayA M Pertsov
Mar 7, 1995·Journal of Theoretical Biology·J SunJ Billette
May 22, 1995·Proceedings. Biological Sciences·V N Biktashev, A V Holden
Jul 21, 1994·Journal of Theoretical Biology·V N Biktashev, A V Holden
Aug 25, 1994·Nature·S J SchiffW L Ditto
Oct 1, 1993·Journal of Cardiovascular Electrophysiology·P V BaylyR E Ideker
Jan 27, 1994·The New England Journal of Medicine·D S RosenbaumR J Cohen
Sep 17, 1996·Proceedings of the National Academy of Sciences of the United States of America·H M HastingsO Nwasokwa
Nov 1, 1996·Journal of Cardiovascular Electrophysiology·D S RosenbaumR J Cohen
Dec 1, 1996·Current Opinion in Genetics & Development·A Sidow
Nov 1, 1996·Journal of Mathematical Biology·M Watanabe, R F Gilmour
Jan 15, 1997·The Journal of Clinical Investigation·A GarfinkelJ N Weiss
Mar 24, 1998·Nature·F X WitkowskiA T Winfree
Jan 1, 1999·Proceedings. Biological Sciences·S J EvansA Garfinkel
Aug 1, 1994·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·B HübingerU Dressler
Sep 1, 1994·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·D J GauthierJ E Socolar
Oct 1, 1994·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·J E SocolarD J Gauthier
Nov 1, 1994·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·P ColetK Wiesenfeld
Dec 1, 1995·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·D J Christini, J J Collins
Jan 1, 1996·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·D J Christini, J J Collins
Nov 1, 1996·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·R M Mantel, D Barkley
Nov 1, 1996·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·D J ChristiniP S Linsay
Mar 12, 1990·Physical Review Letters·E OttJ A Yorke
Dec 24, 1990·Physical Review Letters·W L DittoM L Spano
Oct 2, 1995·Physical Review Letters·D J Christini, J J Collins
Oct 30, 1995·Physical Review Letters·S GrillS C Müller
Aug 7, 1995·Physical Review Letters·F X WitkowskiD T Kaplan
Mar 17, 1999·Circulation·J M PastoreD S Rosenbaum
Apr 13, 1999·Annals of Biomedical Engineering·D J ChristiniB B Lerman
Oct 14, 2000·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·D J Christini, D T Kaplan

❮ Previous
Next ❯

Citations

Apr 22, 2010·Annals of Biomedical Engineering·Laura M MuñozNiels F Otani
Apr 1, 2007·Journal of Biological Physics·Victor D HosfeldBradley J Roth
Jun 5, 2003·Chaos·Humberto ArceMichael R. Guevara
Jun 5, 2003·Chaos·Blas Echebarria, Alain Karma
Jun 5, 2003·Chaos·David J. Christini, Leon Glass
Jun 11, 2004·Chaos·Jose L Perez Velazquez, Houman Khosravani
Feb 28, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Lewis A Lipsitz
Jul 27, 2005·IEEE Transactions on Bio-medical Engineering·Anil MaybhateDavid J Christini
Jul 22, 2005·Cephalalgia : an International Journal of Headache·D Kernick
Jun 8, 2011·Circulation·Sanjiv M NarayanDavid E Krummen
Mar 1, 2014·Journal of Theoretical Biology·Stephen D McIntyreElena G Tolkacheva
Apr 25, 2012·Annual Review of Biomedical Engineering·Trine Krogh-Madsen, David J Christini
Oct 1, 2014·Physics Reports·Zhilin QuJames N Weiss
Jul 11, 2006·Journal of Biomedical Optics·Vadim D KhaitArkady M Pertsov
May 7, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Bradley J Roth
Jan 1, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Zhilin Qu
Jan 1, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Antonis A ArmoundasFaisal M Merchant
Oct 16, 2004·Journal of Cardiovascular Electrophysiology·Peter N Jordan, David J Christini
Oct 16, 2004·Journal of Cardiovascular Electrophysiology·Zhilin Qu
May 7, 2014·Journal of Evaluation in Clinical Practice·David KaterndahlRobert Wood
Apr 4, 2009·IEEE Transactions on Bio-medical Engineering·Steffan Puwal, Bradley J Roth
Jul 10, 2003·IEEE Transactions on Bio-medical Engineering·David J ChristiniBruce B Lerman
Nov 23, 2006·Mathematical Biosciences·Xinwei HanXiaomei Wu
Jul 5, 2005·Lancet·G Karthikeyan
Jun 13, 2015·Computers in Biology and Medicine·Azzam HazimStevan Dubljevic
Jan 14, 2003·Biophysical Journal·Houman KhosravaniJose L Perez Velazquez
Apr 30, 2016·The Journal of Physiology·Michael R GuevaraLeon Glass
Apr 20, 2004·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Elena G TolkachevaDaniel J Gauthier
May 15, 2002·Physical Review Letters·Blas Echebarria, Alain Karma
May 15, 2002·Physical Review Letters·G Martin Hall, Daniel J Gauthier
Mar 22, 2012·American Journal of Botany·Rebecca E DrenovskyJeremy J James
Feb 9, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·D Allexandre, N F Otani
Apr 12, 2006·Physical Review Letters·David J ChristiniRobert F Gilmour
Apr 7, 2010·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Trine Krogh-MadsenRobert F Gilmour
Jan 24, 2004·Biological Research for Nursing·Autumn Schumacher
Nov 13, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Carolyn M BergerDaniel J Gauthier
Jul 24, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Shahriar Iravanian, David J Christini
Dec 11, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Faisal M MerchantAntonis A Armoundas
Sep 19, 2015·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·S N GomesG A Pavliotis
Jun 24, 2017·Frontiers in Neuroscience·Jose L Perez Velazquez
Oct 17, 2019·Journal of the American Heart Association·Kanchan KulkarniAntonis A Armoundas
Aug 2, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Hui-Nam PakShien-Fong Lin
Nov 4, 2020·Chaos·P ParthibanE G Tolkacheva

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.