Nonlinear dynamics underlying sensory processing dysfunction in schizophrenia.

Proceedings of the National Academy of Sciences of the United States of America
Claudia LainscsekGregory A Light

Abstract

Natural systems, including the brain, often seem chaotic, since they are typically driven by complex nonlinear dynamical processes. Disruption in the fluid coordination of multiple brain regions contributes to impairments in information processing and the constellation of symptoms observed in neuropsychiatric disorders. Schizophrenia (SZ), one of the most debilitating mental illnesses, is thought to arise, in part, from such a network dysfunction, leading to impaired auditory information processing as well as cognitive and psychosocial deficits. Current approaches to neurophysiologic biomarker analyses predominantly rely on linear methods and may, therefore, fail to capture the wealth of information contained in whole EEG signals, including nonlinear dynamics. In this study, delay differential analysis (DDA), a nonlinear method based on embedding theory from theoretical physics, was applied to EEG recordings from 877 SZ patients and 753 nonpsychiatric comparison subjects (NCSs) who underwent mismatch negativity (MMN) testing via their participation in the Consortium on the Genetics of Schizophrenia (COGS-2) study. DDA revealed significant nonlinear dynamical architecture related to auditory information processing in both groups...Continue Reading

References

Apr 18, 2001·Psychiatry Research·V KnottK Evans
Jan 7, 2003·Biological Psychiatry·Martin P Paulus, David L Braff
Feb 5, 2003·Biological cybernetics·John R Terry, Michael Breakspear
Jan 24, 2006·Biological Psychiatry·Klaas E StephanKarl J Friston
Jan 16, 2010·Biological Psychiatry·Jonathan K WynnMichael F Green
Jun 10, 2011·Schizophrenia Bulletin·Lauren V Moran, L Elliot Hong
Oct 25, 2011·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Juanita ToddStanley V Catts
Mar 1, 2012·Biological Psychiatry·Kenji KiriharaGregory A Light
May 23, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Anthony J RisslingGregory A Light
Jul 5, 2013·Chaos·Claudia Lainscsek, Terrence J Sejnowski
Jan 1, 2014·Frontiers in Neurology·Claudia LainscsekTerrence J Sejnowski
Jun 11, 2014·Schizophrenia Bulletin·Naoya OribeMargaret Niznikiewicz
Jan 21, 2015·Neural Computation·Claudia Lainscsek, Terrence J Sejnowski
Jun 13, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Neal R SwerdlowGregory A Light
Feb 1, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Veronica B PerezGregory A Light
Feb 24, 2017·Nature Neuroscience·Michael Breakspear
Apr 21, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gregory A LightNeal R Swerdlow
Aug 5, 2017·Neural Computation·Claudia LainscsekTerrence J Sejnowski
Feb 2, 2019·Journal of Neuroscience Methods·Aaron L SampsonTerrence J Sejnowski

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Citations

Jan 3, 2020·Chaos·Claudia LainscsekTerrence J Sejnowski
Jan 17, 2021·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Daisuke KoshiyamaGregory A Light
Aug 25, 2020·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Daisuke KoshiyamaGregory A Light

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