PMID: 15217231Jun 26, 2004Paper

Nonlinear elasticity imaging: theory and phantom study

IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Ramon Q ErkampM O'Donnell

Abstract

In tissue the Young's modulus cannot be assumed constant over a wide deformation range. For example, direct mechanical measurements on human prostate show up to a threefold increase in Young's modulus over a 10% deformation. In conventional elasticity imaging, these effects produce strain-dependent elastic contrast. Ignoring these effects generally leads to suboptimal contrast (stiffer tissues at lower strain are contrasted against softer tissues at higher strain), but measuring the nonlinear behavior results in enhanced tissue differentiation. To demonstrate the methods extracting nonlinear elastic properties, both simulations and measurements were performed on an agar-gelatin phantom. Multiple frames of phase-sensitive ultrasound data are acquired as the phantom is deformed by 12%. All interframe displacement data are brought back to the geometry of the first frame to form a three-dimensional (3-D) data set (depth, lateral, and preload dimensions). Data are fit to a 3-D second order polynomial model for each pixel that adjusts for deformation irregularities. For the phantom geometry and elastic properties considered in this paper, reconstructed frame-to-frame strain images using this model result in improved contrast to noise...Continue Reading

References

Jan 1, 1995·Ultrasound in Medicine & Biology·H PonnekantiI Céspedes
Jul 17, 1998·Ultrasonic Imaging·R Q ErkampM O'Donnell
Apr 10, 1999·Ultrasonic Imaging·T A KrouskopT Hall
May 14, 2004·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Ramon Q ErkampMatthew O'Donnell
Feb 2, 2008·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·M A LubinskiM O'Donnell
Jan 1, 1997·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·T Varghese, J Ophir

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Citations

Feb 3, 2009·Physics in Medicine and Biology·Assad A OberaiJingfeng Jiang
Apr 20, 2010·Physics in Medicine and Biology·Theo Z PavanTimothy J Hall
Jul 20, 2011·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Siming LiuZhenggan Zhou
Nov 7, 2008·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·H EskandariR Rohling
Jun 6, 2012·IEEE Transactions on Medical Imaging·Sevan GoenezenAssad A Oberai
Dec 24, 2013·Medical Image Analysis·Hassan RivazGregory D Hager
May 7, 2014·Ultrasound in Medicine & Biology·Richard G P LopataFrans N van de Vosse

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