PMID: 6538070Jan 1, 1984Paper

Nonlinear force response of active smooth muscle subjected to small stretches

The American Journal of Physiology
R A Meiss

Abstract

Isometrically mounted and electrically stimulated strips of rabbit mesotubarium superius muscles were subjected to sinusoidal length perturbations (delta L) of variable amplitude (0-1% of Lmax) at constant frequency (80 Hz). In both the plateau phase of long-maintained (steady-state) contractions and in brief contraction-relaxation cycles the force perturbation amplitude (delta F) response was directly proportional to delta L (and to the developed force, F) for delta L values less than approximately 0.30% of Lmax. At larger delta L values the magnitude of the delta F response deviated downward from a linear relationship. Statistical analysis of the relationship characterized a "deviation point," the value of delta F and delta L beyond which the delta F response departed from linearity. The value of delta F at the deviation point depended strongly on the developed force, whether it was varied by changing muscle rest length, stimulus strength, or time during a phasic contraction-relaxation cycle. The value of delta L at the deviation point was independent of developed force. Restricting the length of muscle subjected to delta L (while not changing cellular dimensions) showed that the slope of delta F/delta L relationship (the act...Continue Reading

References

Mar 1, 1978·The Journal of Physiology·F W Flitney, D G Hirst
Nov 1, 1978·Biophysical Journal·S P DriskaR A Murphy
Mar 1, 1973·The American Journal of Physiology·G H TempletonL L Hefner
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May 1, 1981·The Journal of Physiology·M J Mulvany, D M Warshaw

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Citations

May 1, 1988·Medical & Biological Engineering & Computing·Y GoldsteinS Sideman
Aug 31, 2004·Journal of Applied Physiology·Richard A Meiss, Ramana M Pidaparti
Nov 25, 2005·Journal of Pharmacokinetics and Pharmacodynamics·Lambertus A PeletierJacintha den Haag
Sep 9, 2017·Journal of Pharmacokinetics and Pharmacodynamics·Lambertus A Peletier, Johan Gabrielsson
Apr 1, 1992·Journal of Muscle Research and Cell Motility·R A Meiss
Sep 1, 1986·Basic Research in Cardiology·W P SantamoreD Hughes
Aug 5, 2011·Anesthesia and Analgesia·Robina MatyalFeroze Mahmood
Feb 1, 1995·Journal of Pharmacokinetics and Biopharmaceutics·D Verotta, L B Sheiner
Jan 14, 1999·Journal of Applied Physiology·R A Meiss
Oct 21, 2006·Journal of Pharmacokinetics and Pharmacodynamics·Anasuya HazraWilliam J Jusko
Jan 13, 2006·Journal of Pharmacokinetics and Pharmacodynamics·Chantal Csajka, Davide Verotta
Sep 18, 1997·Journal of Applied Physiology·X ShenS J Gunst
Aug 1, 1995·Clinical Pharmacology and Therapeutics·L B Sheiner, D Verotta
Nov 5, 2003·Journal of Applied Physiology·Richard A Meiss, Ramana M Pidaparti
Jun 21, 2006·European Journal of Anaesthesiology·J C KubitzD A Reuter

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