Dec 14, 2004

Nonlinear modeling of the atrioventricular node physiology in atrial fibrillation

Journal of Theoretical Biology
Armin Rashidi, Iman Khodarahmi


A nonlinear model of the atrioventricular (AV) node physiology in atrial fibrillation (AF) is proposed based on three assumptions: (1) normal distribution of atrial impulses, (2) right-skewed distribution of R-R intervals, (3) increase in the refractory period of the AV node due to rapid bombardment from the atria. Simulation resulted in the following conclusions, all of which are in agreement with previous experience: (1) the entry speed of atrial impulses into the AV node in AF is inversely proportional to the ventricular rate, (2) the autocorrelation function of R-R intervals is zero at all delays, (3) a newly introduced index, sign of first difference, has a negative autocorrelation function at the first delay and zero ones at all others. In spite of its simplicity, the model is able to explain what happens in atrial premature complexes, sinus tachycardia and sinus bradycardia. Different rhythms, some of which rarely seen clinically, can be reproduced by changing input patterns or by slightly manipulating the model parameters. In order to make possible a long irregular time series of R-R interval, aperiodic changes in atrial signals are shown to be necessary. In conclusion, we proposed a simple model for the AV node physiol...Continue Reading

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Mentioned in this Paper

Supraventricular Tachycardia
Atrial Fibrillation
Refractory Period
Sinus Tachycardia
Structure of Atrioventricular Node
Electrophysiology (Science)
Entire Atrioventricular Node
Heart Ventricle
Idioventricular Rhythm
Heart Atrium

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