Nonlinear modeling was applied thoughtfully for risk prediction: the Prostate Biopsy Collaborative Group.

Journal of Clinical Epidemiology
Daan NieboerProstate Biopsy Collaborative Group

Abstract

We aimed to compare nonlinear modeling methods for handling continuous predictors for reproducibility and transportability of prediction models. We analyzed four cohorts of previously unscreened men who underwent prostate biopsy for diagnosing prostate cancer. Continuous predictors of prostate cancer included prostate-specific antigen and prostate volume. The logistic regression models included linear terms, logarithmic terms, fractional polynomials of degree one or two (FP1 and FP2), or restricted cubic splines (RCS) with three or five knots (RCS3 and RCS5). The resulting models were internally validated by bootstrap resampling and externally validated in the cohorts not used at model development. Performance was assessed with the area under the receiver operating characteristic curve (AUC) and the calibration component of the Brier score (CAL). At internal validation models with FP2 or RCS5 showed slightly better performance than the other models (typically 0.004 difference in AUC and 0.001 in CAL). At external validation models containing logarithms, FP1, or RCS3 showed better performance (differences 0.01 and 0.002). Flexible nonlinear modeling methods led to better model performance at internal validation. However, when ap...Continue Reading

References

Oct 5, 1988·Journal of the National Cancer Institute·F E HarrellB G Pollock
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Mar 13, 1999·Annals of Internal Medicine·A C JusticeJ A Berlin
Apr 20, 2006·Journal of the National Cancer Institute·Ian M ThompsonCharles A Coltman
Jun 1, 2007·Statistics in Medicine·Usha S GovindarajuluEllen A Eisen
Mar 7, 2008·BJU International·Georg BartschUNKNOWN Tyrol Prostate Cancer Screening Group
Mar 20, 2009·The New England Journal of Medicine·Fritz H SchröderUNKNOWN ERSPC Investigators
Aug 26, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Andrew J VickersHans Lilja
Sep 3, 2010·American Journal of Epidemiology·Yvonne VergouweEwout W Steyerberg
Aug 29, 2013·Statistics in Medicine·Daan NieboerYvonne Vergouwe
Sep 3, 2014·Journal of Clinical Epidemiology·Thomas P A DebrayKarel G M Moons

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