Nonlinear response properties of combination-sensitive electrosensory neurons in the midbrain of Gymnarchus niloticus

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Bruce A Carlson, M Kawasaki

Abstract

The jamming avoidance response of the weakly electric fish Gymnarchus niloticus relies on determining the sign of the frequency difference (Df) between the fish's own electric organ discharge (EOD) and that of a neighbor, which is achieved by comparing modulations in amplitude (AM) and phase (PM) that result from the summation of their EODs. These two stimulus features are processed in separate pathways that converge in the torus semicircularis on combination-sensitive neurons, many of which are selective for the sign of Df. We recorded extracellular single-unit responses to independent stimulation with AM and PM and combined AM-PM stimulation to determine how sign selectivity is established. Responses to AM and PM frequently summated nonlinearly, leading to sign-selective responses as a result of facilitation to the preferred sign of Df and/or suppression to the nonpreferred sign of Df. Facilitation typically occurred when responses to AM and PM were aligned, whereas suppression typically occurred when they were offset. By experimentally manipulating the degree of alignment between these two responses, we found that the summed response was dependent on their relative timing. In addition, we found a unique class of units that w...Continue Reading

Citations

Feb 2, 2006·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·E S FortuneM Kawasaki
Nov 20, 2004·Nature Reviews. Neuroscience·Gary J Rose
Jan 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason Tait SanchezJeffrey J Wenstrup
Oct 6, 2009·Zoological Science·Masashi Kawasaki
Sep 29, 2006·Journal of Neurophysiology·Bruce A Carlson, Masashi Kawasaki

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