Nonlinearity of radiation health effects

Environmental Health Perspectives
M Pollycove

Abstract

The prime concern of radiation protection policy since 1959 has been to protect DNA from damage. In 1994 the United Nations Scientific Community on the Effects of Atomic Radiation focused on biosystem response to radiation with its report Adaptive Responses to Radiation of Cells and Organisms. The 1995 National Council on Radiation Protection and Measurements report Principles and Application of Collective Dose in Radiation Protection states that because no human data provides direct support for the linear nonthreshold hypothesis (LNT), confidence in LNT is based on the biophysical concept that the passage of a single charged particle could cause damage to DNA that would result in cancer. Several statistically significant epidemiologic studies contradict the validity of this concept by showing risk decrements, i.e., hormesis, of cancer mortality and mortality from all causes in populations exposed to low-dose radiation. Unrepaired low-dose radiation damage to DNA is negligible compared to metabolic damage. The DNA damage-control biosystem is physiologically operative on both metabolic and radiation damage and effected predominantly by free radicals. The DNA damage-control biosystem is suppressed by high dose and stimulated by l...Continue Reading

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Citations

May 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Michael D Devous
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Mar 29, 2018·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Eman I KandilOla Ms Khedr
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May 20, 2020·Dose-response : a Publication of International Hormesis Society·Paul A Oakley, Deed E Harrison
Jan 11, 2019·Dose-response : a Publication of International Hormesis Society·Jonathan StoneJanis Eells

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