Nonmagnetic Hypertonic Saline-Based Implant for Breast Cancer Postsurgical Recurrence Prevention by Magnetic Field/pH-Driven Thermochemotherapy

ACS Applied Materials & Interfaces
Fei GaoLingyun Zhao

Abstract

Magnetic-mediated hyperthermia (MMT) is emerging as one of the promising techniques, which could synergistically treat cancer along with current treatment techniques such as chemotherapy and radiotherapy and trigger on-demand release of therapeutic macromolecules. However, the low specific absorption rate and potential in vivo toxicity of magnetic nanomaterials as the MMT mediators restrict the new advancements in MMT treatment. Herein, for the first trial, the unique inductive heating property of hypertonic saline (HTS), a clinically applied solution exhibiting several physiological effects under alternative magnetic field (AMF), was systematically investigated. Though without magnetic property, due to the dipolar polarization under the electromagnetic radiation, HTS can induce enough high and rapid temperature increase upon exposure under AMF. Based on such an observation, PEG-based HTS hydrogel was fabricated for the inhibition of unwanted diffusion of ions so as to ensure the ideal temperature rise at the targeted region for a longer time. Furthermore, an anticancer drug (doxorubicin) was also incorporated into the hydrogel to achieve the magnetic field/pH stimuli-responsive drug-sustainable release as well as synergistic t...Continue Reading

References

Jun 25, 2002·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·P MorozB N Gray
Apr 13, 2004·Current Opinion in Critical Care·Anish Bhardwaj, John A Ulatowski
Nov 2, 2004·Journal of Materials Science. Materials in Medicine·L L Lao, R V Ramanujan
Jul 9, 2008·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Burghard Thiesen, Andreas Jordan
Nov 26, 2008·Nanomedicine·Florence GazeauClaire Wilhelm
Feb 26, 2009·The Journal of Physical Chemistry. B·Yanbin WuN R Aluru
Nov 6, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ferdinand BrandlAchim Göpferich
Feb 3, 2011·Advanced Materials·Séverine BruléCatherine Le Visage
Jun 28, 2011·Nature Nanotechnology·Jae-Hyun LeeJinwoo Cheon
May 28, 2014·JAMA Pediatrics·Susan WuWilbert H Mason
Jun 8, 2014·Carbohydrate Polymers·Yangling LiPixin Wang
Jun 7, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jaber BeikS Kamran Kamrava
Jun 20, 2017·ACS Nano·Sheng TongGang Bao
Oct 20, 2017·Chemical Reviews·Wenpei FanXiaoyuan Chen
Jun 14, 2016·Advanced Functional Materials·Andreina Chiu-Lam, Carlos Rinaldi
Dec 20, 2017·ACS Nano·Christopher M HartshornPiotr Grodzinski
Feb 2, 2018·Advanced Materials·Joël BourquinBarbara Rothen-Rutishauser
Feb 8, 2018·ACS Applied Materials & Interfaces·Yingqiu QiGuangjun Nie
Mar 22, 2018·ACS Applied Materials & Interfaces·Eduardo GuisasolaMaría Vallet-Regí
Dec 1, 2016·Nature Reviews. Materials·Jianyu Li, David J Mooney
Jul 17, 2018·ACS Applied Materials & Interfaces·Yongsan LiLei Tao

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Citations

Jul 19, 2020·Journal of Biomedical Materials Research. Part a·Bowen TanJinfeng Liao
Jul 1, 2020·Advanced Science·Jiaojiao WuYu Cheng

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