Nonmedical prescription sedative/tranquilizer use in alcohol and opioid use disorders

Addictive Behaviors
Victoria R VotawR Kathryn McHugh

Abstract

Nonmedical prescription sedative/tranquilizer (e.g., benzodiazepines) use (NMSTU) increases risk of overdose when combined with opioids and/or alcohol. Yet, little is known about NMSTU among those with alcohol and opioid use disorders. We aimed to characterize NMSTU and sedative/tranquilizer use disorder among adults with alcohol use disorder (AUD) and/or opioid use disorder (OUD) in a general population sample. We conducted analyses of 2008-2014 National Survey on Drug Use and Health data; adults with past-year AUD-only (n = 27,416), OUD-only (n = 2142), and co-occurring AUD and OUD (n = 1483) were included (total N = 31,041). Multivariable logistic regression models were utilized to examine correlates of past-month NMSTU and past-year sedative/tranquilizer use disorder. Focal independent variables were polysubstance use (i.e., number of substances used in the previous year) and psychiatric distress. Among those with AUD-only, 27.1% reported lifetime NMSTU, 7.6% reported past-year NMSTU, 2.7% reported past-month NMSTU, and 0.6% met criteria for past-year sedative/tranquilizer use disorder. Corresponding prevalence rates among those with OUD-only were 69.5%, 43.0%, 22.6%, and 11.3%. Those with co-occurring AUD and OUD displayed...Continue Reading

Citations

Oct 4, 2019·Science Advances·K WitkiewitzL Leggio
Dec 17, 2019·Alcoholism, Clinical and Experimental Research·Scott EdwardsKatie Witkiewitz
Jan 5, 2020·Substance Use & Misuse·Victoria R VotawKatie Witkiewitz
Dec 22, 2020·Journal of Clinical Pharmacy and Therapeutics·Joseph V PergolizziRobert B Raffa
Jan 8, 2021·Psychopharmacology·Annika Billefeld BornebuschMorgane Thomsen
Aug 31, 2020·Addictive Behaviors·R Kathryn McHughRoger D Weiss
Jul 21, 2021·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Noa KrawczykFrancisco Inácio Bastos

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