Nonmotor symptoms in subjects without evidence of dopaminergic deficits

Movement Disorders : Official Journal of the Movement Disorder Society
Fabienne S SprengerWerner Poewe

Abstract

A subgroup of patients initially diagnosed with Parkinson's disease (PD) turn out to have normal dopamine transporter single-photon emission computed tomography imaging and have been labeled as subjects without evidence of dopaminergic deficit (SWEDDs). In this study, we sought to further characterize these patients and have analyzed the frequency of nonmotor symptoms (NMS) in SWEDDs, PD patients, and healthy controls. We analyzed the baseline clinical data of 412 PD patients, 184 controls, and 62 SWEDDs included in the Parkinson's Progression Marker Initiative study on a variety of different NMS questionnaires. Both PD patients and SWEDDs had greater frequency of NMS than healthy controls. Furthermore, some NMS, such as orthostatic hypotension as well as cardiovascular and thermoregulatory dysfunction were even more commonly reported in SWEDDs than in PD patients, whereas hyposmia was more common in PD, compared to SWEDDs. NMS are more frequent in SWEDDs than in controls, and autonomic dysfunction and orthostatic hypotension were even more common than in PD patients. These findings support the notion that SWEDDS represent a group of patients with still poorly understood pathophysiology. © 2015 International Parkinson and Movem...Continue Reading

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Citations

Dec 17, 2016·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Kathryn A Wyman-ChickRyan W Schroeder
Dec 20, 2017·Frontiers in Aging Neuroscience·Jose A SantiagoJudith A Potashkin
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Oct 6, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Thomas G Beach, Charles H Adler
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Oct 22, 2016·Journal of Parkinson's Disease·Yoon-Sang OhDo-Young Kwon
Aug 23, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Fabienne S SprengerWerner Poewe
Aug 23, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Ruth B Schneider, Irene Hegeman Richard
Feb 20, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Diane M A SwallowDonald G Grosset
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Aug 16, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Daryl J WileA Jon Stoessl
Apr 20, 2021·Parkinson's Disease·Zimple KurlawalaRobert P Friedland

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