Abstract
Recent studies have shown that myofibroblasts cultured from spastic arteries after subarachnoid hemorrhage (SAH) can produce contractile forces and that cerebrospinal fluid obtained from SAH patients accelerates this contraction. Myofibroblast-populated collagen lattices were used to evaluate the roles of polypeptide growth factors considered to be released from intraluminal accumulated platelets. The myofibroblasts, obtained at autopsy from human cerebral arteries of victims of vasospasm, caused contractile forces by compacting collagen fibrils in the matrix. Transforming growth factor beta 1 (TGF-beta 1) and platelet-derived growth factors aa and bb (PDGFaa and PDGFbb) accelerated this contraction in a dose-dependent manner. In the presence of TGF-beta 1 at 1 or 10 ng/ml, PDGFaa at 10 ng/ml, or PDGFbb at 10 ng/ml, lattice areas were reduced to 69.5 +/- 1.9% (mean +/- standard deviation) (P < 0.001), 63.3 +/- 0.4% (P < 0.001), 66.5 +/- 3.0% (P < 0.01), or 74.4 +/- 1.7% (P < 0.01) of the control on Day 6, respectively. The combination of subthreshold doses of TGF-beta 1 and PDGFaa created a stimulatory effect that appeared to act synergistically. Furthermore, myofibroblast-populated collagen lattices made with cells preincubate...Continue Reading
References
Mar 1, 1992·Neurosurgery·Y YamamotoD H Bernanke
Jul 1, 1991·Stroke; a Journal of Cerebral Circulation·H OhkumaE Sobata
Mar 1, 1990·Neurological Research·R R SmithD H Bernanke
Apr 1, 1991·Stroke; a Journal of Cerebral Circulation·S JuvelaM Kaste
Oct 1, 1990·Journal of Cellular Physiology·O IshikawaM Trojanowska
Dec 1, 1990·Neurosurgery·Y YamamotoR R Smith
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A B RobertsJ H Kehrl
Jun 1, 1988·The Journal of Cell Biology·D C DeanS Bourgeois
Apr 1, 1989·Neurosurgery·Y HonmaR R Smith
Aug 1, 1989·The Journal of Clinical Investigation·S E LynchH N Antoniades
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R A Ignotz, J Massagué
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·E B LeofH L Moses
Jul 18, 1986·Cell·R RossD F Bowen-Pope
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J MassaguéB Nadal-Ginard
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R Montesano, L Orci
Jul 1, 1988·Stroke; a Journal of Cerebral Circulation·J L HainingR R Smith
Jul 1, 1987·Endocrinology·J PfeilschifterG R Mundy
Aug 1, 1986·Journal of Cellular Physiology·D J HillR D Milner
Nov 1, 1987·The Biochemical Journal·J VargaS A Jimenez
Oct 1, 1985·Circulation·P M Vanhoutte, D S Houston
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A B RobertsM B Sporn
Feb 1, 1985·Neurosurgery·R R SmithJ M Cruse
Nov 9, 1984·Science·R F TuckerR W Holley
May 1, 1984·Cell·C H Heldin, B Westermark
Sep 1, 1982·Stroke; a Journal of Cerebral Circulation·S NagasawaK Hayashi
Citations
Oct 22, 2003·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Alexander Y. ZubkovJohn H. Zhang
Dec 3, 2011·Cerebrovascular Diseases·Anelia DietmannRonny Beer
Oct 26, 2012·European Neurology·Hiroji YanamotoKoji Iihara
Mar 24, 2010·Brain Research·Koji OsukaMasakazu Takayasu
Jun 29, 2001·Neurological Research·K AokiJ H Zhang
Oct 21, 1999·Biochemical and Biophysical Research Communications·A PatlollaJ H Zhang
Sep 1, 1995·Journal of Neurosurgery·P D ChanR A Ashforth
Sep 2, 1999·Journal of Neurosurgery·K OgiharaJ H Zhang
Dec 15, 2007·Journal of Neurosurgery·Ming-Yuan TsengPeter J Kirkpatrick
Jun 1, 1995·Journal of Neurosurgery·S Juvela
Jul 17, 2004·Journal of Neurosurgery·Masahiro ShinTakaaki Kirino
Nov 1, 1996·Stroke; a Journal of Cerebral Circulation·K OnodaY Ninomiya
Oct 7, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·William J PearceJiping Tang
Jul 30, 2005·Journal of Applied Physiology·Mitsuo Yamaguchi-OkadaYuichiro Nonaka