PMID: 8474652Apr 1, 1993Paper

Nonmuscle arterial constriction after subarachnoid hemorrhage: role of growth factors derived from platelets

Neurosurgery
K IwasaY Yamamoto

Abstract

Recent studies have shown that myofibroblasts cultured from spastic arteries after subarachnoid hemorrhage (SAH) can produce contractile forces and that cerebrospinal fluid obtained from SAH patients accelerates this contraction. Myofibroblast-populated collagen lattices were used to evaluate the roles of polypeptide growth factors considered to be released from intraluminal accumulated platelets. The myofibroblasts, obtained at autopsy from human cerebral arteries of victims of vasospasm, caused contractile forces by compacting collagen fibrils in the matrix. Transforming growth factor beta 1 (TGF-beta 1) and platelet-derived growth factors aa and bb (PDGFaa and PDGFbb) accelerated this contraction in a dose-dependent manner. In the presence of TGF-beta 1 at 1 or 10 ng/ml, PDGFaa at 10 ng/ml, or PDGFbb at 10 ng/ml, lattice areas were reduced to 69.5 +/- 1.9% (mean +/- standard deviation) (P < 0.001), 63.3 +/- 0.4% (P < 0.001), 66.5 +/- 3.0% (P < 0.01), or 74.4 +/- 1.7% (P < 0.01) of the control on Day 6, respectively. The combination of subthreshold doses of TGF-beta 1 and PDGFaa created a stimulatory effect that appeared to act synergistically. Furthermore, myofibroblast-populated collagen lattices made with cells preincubate...Continue Reading

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Citations

Oct 22, 2003·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Alexander Y. ZubkovJohn H. Zhang
Mar 24, 2010·Brain Research·Koji OsukaMasakazu Takayasu
Jun 29, 2001·Neurological Research·K AokiJ H Zhang
Oct 21, 1999·Biochemical and Biophysical Research Communications·A PatlollaJ H Zhang
Sep 2, 1999·Journal of Neurosurgery·K OgiharaJ H Zhang
Oct 7, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·William J PearceJiping Tang
Jul 30, 2005·Journal of Applied Physiology·Mitsuo Yamaguchi-OkadaYuichiro Nonaka

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