Nonmyeloablative stem cell transplantation in metastatic renal cell carcinoma: delayed graft-versus-tumor effect is associated with chimerism conversion but transplantation has high toxicity

Bone Marrow Transplantation
Gero MassenkeilR Arnold

Abstract

Seven out of 29 patients with metastatic renal cell carcinoma (RCC) considered eligible for allogeneic stem cell transplantation underwent nonmyeloablative stem cell transplantation (NST) from HLA-identical donors. Conditioning comprised cyclophosphamide, fludarabine and antithymocyte globulin. Prolonged mixed chimerism (MC) after engraftment converted to complete donor chimerism (CC) after infusion of donor lymphocytes and/or graft-versus-host disease (GvHD) in six patients. Five patients developed severe GvHD. Two of seven patients had a delayed tumor response after conversion to CC. After a median follow-up of 10 months (4-24 months), 5/7 patients are alive, one in very good partial remission (PR), one with stable and three with progressive disease. One of the seven patients died from sepsis in PR and 1/7 died from rapid tumor progression after sustained MC. None of the 22 nontransplanted patients responded to further therapies. Survival after 1 year was 59% in transplanted and 66% in nontransplanted patients (n.s.). A pooled data analysis from the literature suggests a graft-versus-tumor effect after transplant in patients with metastatic RCC, which becomes effective after chimerism conversion. Available data demonstrate hi...Continue Reading

References

Sep 1, 1976·Nucleic Acids Research·N Blin, D W Stafford
Aug 1, 1980·The American Journal of Medicine·H M ShulmanE D Thomas
Feb 22, 1996·The New England Journal of Medicine·J HincheyL R Caplan
Jul 10, 1999·Journal of Neurology·J M GijtenbeekC J Vecht
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R A FiglinA S Belldegrun
Mar 4, 2000·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·J S López-GonzálezJ V Caloca
Aug 5, 2000·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·E OrsiniJ Ritz
Oct 5, 2001·Lancet·G H MickischUNKNOWN European Organisation for Research and Treatment of Cancer (EORTC) Genitourinary Group
Apr 17, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brian I RiniNicholas J Vogelzang
Mar 1, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alfred E ChangBruce G Redman

❮ Previous
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Citations

Nov 26, 2005·Journal of Cancer Research and Clinical Oncology·A J SchraderR Hofmann
Apr 10, 2008·Nature Clinical Practice. Oncology·Taner DemirerUNKNOWN EBMT Solid Tumors Working Party
Sep 6, 2006·Bone Marrow Transplantation·M BregniR Childs
Mar 2, 2011·Cancer Biotherapy & Radiopharmaceuticals·Robert O Dillman
Oct 31, 2006·Expert Review of Anticancer Therapy·Jan RoigasGero Massenkeil
Dec 13, 2005·Expert Review of Anticancer Therapy·Robert O Dillman
Jun 29, 2011·Expert Review of Anticancer Therapy·Marco BregniUNKNOWN Solid Tumor Working Party of EBMT
Mar 23, 2011·Expert Opinion on Biological Therapy·Scott S TykodiJohn A Thompson
Dec 15, 2010·Seminars in Nephrology·Eliot C Heher, Thomas R Spitzer
Jun 21, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Brian I RiniUNKNOWN Southwestern Oncology Group
Jan 16, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Brenda M SandmaierRichard W Childs
Jul 21, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Kazutaka NakayamaNaoto T Ueno
Dec 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James C Yang, Richard Childs
Sep 3, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Zhiwei ZhangXin Song

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