Nonnightmare distressed awakenings in veterans with posttraumatic stress disorder: response to prazosin.

Journal of Traumatic Stress
C E ThompsonMurray A Raskind

Abstract

Twenty-two veterans with posttraumatic stress disorder (PTSD) were assessed for trauma-related nightmares and nonnightmare distressed awakenings (NNDA) before and after treatment with the alpha-1 adrenoreceptor antagonist prazosin at an average bedtime dose of 9.6 mg/day. Ratings combining frequency and intensity dimensions of trauma-related nightmares decreased from 3.6 to 2.2, NNDA from 5.2 to 2.1, and sleep difficulty from 7.2 to 4.1 per week. These results suggest that increased brain adrenergic activity may contribute to the pathophysiology of both trauma-related nightmares and NNDA in PTSD.

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Citations

Jul 29, 2009·Current Psychiatry Reports·Thomas W UhdeAndrei Vedeniapin
Nov 10, 2013·Journal of Rehabilitation Research and Development·Alexander K OmmayaGeorge F Wittenberg
Sep 4, 2012·The Primary Care Companion to CNS Disorders·Steven M HudsonKurt A Wargo
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