Nonoccupational Exposure of Agricultural Area Residents to Pesticides: Pesticide Accumulation and Evaluation of Genotoxicity

Archives of Environmental Contamination and Toxicology
Zeynep Banu DoğanlarÜmmühan Ersin Aktaş

Abstract

Although many studies related the toxic effects of pesticides on agricultural workers, little research has been done about agricultural area residents. The purpose of this work was to monitor the presence of pesticides, as well as their genotoxic and cytotoxic potential, in humans with blood samples collected from control and intensive agricultural areas in the Thrace region. Pesticide accumulations were determined by LC-MS/MS. Cytotoxicity and genotoxicity were analyzed by comet assay, and the effect of pesticide accumulation on oxidative stress, DNA repair, and molecular chaperone response were analyzed by qRT-PCR assays in the human blood samples. The agricultural area residents had a significantly higher concentration of pesticides than those in the control area at all three sampling times, and the total pesticide amounts were 4.3 and 10 times significantly higher in blood sampled in the pesticide use period (August 2015 and 2016, respectively) than in the nonuse period (November 2015). The results showed that the pesticide level in blood during the use period led to oxidative stress, DNA damage (mean comet length and % tail DNA), and unfolded/misfolded protein response. Particularly, in pesticide use season, difference bet...Continue Reading

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Citations

Dec 14, 2019·Environmental Science and Pollution Research International·Ana Paola Balderrama-CarmonaEdgar Felipe Morán-Palacio
Sep 6, 2020·Environmental Science and Pollution Research International·Tuğçe Kalefetoğlu Macar
Sep 14, 2020·The Science of the Total Environment·Jheneffer Sonara Aguiar RamosDaniela de Melo E Silva

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