Nonoperative treatment improves pain irrespective of radiographic severity. A cohort study of 1,414 patients with knee osteoarthritis

Acta Orthopaedica
Soren T SkouOle Simonsen

Abstract

The discrepancy between symptoms and radiographic severity of knee osteoarthritis (OA) is well described. However, little is known about whether radiographic severity is predictive of the clinical result of nonoperative treatment. We investigated whether radiographic severity and treatment type were associated with improvements in pain after nonoperative treatment of patients with knee OA. A 5-year consecutive series of patients deemed not eligible for total knee arthroplasty (TKA) by an experienced orthopedic surgeon was contacted 1-5 years later. Radiographic severity, age, sex, and BMI were registered at the consultation. At follow-up, patients were asked to answer a questionnaire on type of treatment and improvements in pain after treatment. Of 1,848 patients who were not eligible for TKA, 1,414 (77%) completed the follow-up questionnaire (mean age 66 (24-96) years; 55% women). Radiographic severity was not associated with improvements in pain even after adjusting for treatment type, age, sex, and BMI (p > 0.1). The odds ratio of improvement was higher by a factor of 2 in patients who received physiotherapy or multimodal treatment than in patients who did not. Radiographic severity was not associated with improvements in pa...Continue Reading

References

Aug 12, 1998·The Journal of Orthopaedic and Sports Physical Therapy·E M RoosB D Beynnon
Jun 13, 2003·Health and Quality of Life Outcomes·Ewa M Roos, Sören Toksvig-Larsen
Dec 1, 1957·Annals of the Rheumatic Diseases·J H KELLGREN, J S LAWRENCE
Nov 14, 2003·Health and Quality of Life Outcomes·Ewa M Roos, L Stefan Lohmander
Mar 5, 2004·The Journal of Bone and Joint Surgery. American Volume·Chen-Ti WangSheng-Mou Hou
Dec 31, 2005·Arthritis and Rheumatism·Jennifer M Hootman, Charles G Helmick
Sep 19, 2009·Annals of the Rheumatic Diseases·W ZhangJ W Bijlsma
Jan 26, 2011·Scandinavian Journal of Rheumatology·G F SnijdersUNKNOWN NOAC Study Group
Feb 8, 2011·British Journal of Sports Medicine·David J Hunter
Apr 19, 2013·Annals of the Rheumatic Diseases·Linda FernandesUNKNOWN European League Against Rheumatism (EULAR)
Sep 3, 2013·The European Journal of General Practice·Søren T SkouOle H Simonsen
Dec 3, 2013·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Aman DhawanBrian J Cole
Jan 28, 2014·Osteoarthritis and Cartilage·T E McAlindonM Underwood

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Citations

Apr 20, 2018·The Journal of Orthopaedic and Sports Physical Therapy·Søren T SkouChristian Barton
Feb 14, 2019·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Jens Ole LaursenHelene Skjøt-Arkil
Dec 24, 2019·Cartilage·Jens Ole LaursenHelene Skjøt-Arkil

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NCT02091830

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