Nonparametric Estimates of Gene × Environment Interaction Using Local Structural Equation Modeling

Behavior Genetics
Daniel A BrileyElliot M Tucker-Drob

Abstract

Gene × environment (G × E) interaction studies test the hypothesis that the strength of genetic influence varies across environmental contexts. Existing latent variable methods for estimating G × E interactions in twin and family data specify parametric (typically linear) functions for the interaction effect. An improper functional form may obscure the underlying shape of the interaction effect and may lead to failures to detect a significant interaction. In this article, we introduce a novel approach to the behavior genetic toolkit, local structural equation modeling (LOSEM). LOSEM is a highly flexible nonparametric approach for estimating latent interaction effects across the range of a measured moderator. This approach opens up the ability to detect and visualize new forms of G × E interaction. We illustrate the approach by using LOSEM to estimate gene × socioeconomic status interactions for six cognitive phenotypes. Rather than continuously and monotonically varying effects as has been assumed in conventional parametric approaches, LOSEM indicated substantial nonlinear shifts in genetic variance for several phenotypes. The operating characteristics of LOSEM were interrogated through simulation studies where the functional f...Continue Reading

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Citations

Apr 7, 2016·Multivariate Behavioral Research·Andrea HildebrandtOliver Wilhelm
Dec 16, 2016·Nature Communications·Simon R CoxIan J Deary
Sep 8, 2017·Behavior Genetics·Liang HeMikko J Sillanpää
Dec 5, 2018·Multivariate Behavioral Research·Maria Bolsinova, Dylan Molenaar
Apr 5, 2019·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Timothy C BatesMichael C Neale
Apr 21, 2020·Clinical Psychological Science : a Journal of the Association for Psychological Science·James W MadolePaige K Harden
Feb 7, 2021·Behavior Genetics·Daniel E GustavsonUNKNOWN IGEMS Consortium
Feb 18, 2018·Psychoneuroendocrinology·Andrew D GrotzingerK Paige Harden
Oct 1, 2017·Journal of Economic Behavior & Organization·Yilan XuBrent W Roberts
May 1, 2019·European Journal of Personality·Anqing ZhengElliot M Tucker-Drob
Jul 12, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Kadri ArumäeUku Vainik

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