Nonparametric modeling of the gap time in recurrent event data.

Lifetime Data Analysis
Pang Du

Abstract

Recurrent event data arise in many biomedical and engineering studies when failure events can occur repeatedly over time for each study subject. In this article, we are interested in nonparametric estimation of the hazard function for gap time. A penalized likelihood model is proposed to estimate the hazard as a function of both gap time and covariate. Method for smoothing parameter selection is developed from subject-wise cross-validation. Confidence intervals for the hazard function are derived using the Bayes model of the penalized likelihood. An eigenvalue analysis establishes the asymptotic convergence rates of the relevant estimates. Empirical studies are performed to evaluate various aspects of the method. The proposed technique is demonstrated through an application to the well-known bladder tumor cancer data.

References

Aug 1, 1991·Statistics in Medicine·O O Aalen, E Husebye
Nov 1, 1988·Statistics in Medicine·O O Aalen
Mar 1, 1999·Journal of the American Statistical Association·Mei-Cheng Wang, Shu-Hui Chang

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Citations

Apr 5, 2011·Biometrics·Pang DuYuedong Wang
Aug 25, 2015·Lifetime Data Analysis·Jieli Ding, Liuquan Sun
Nov 25, 2017·Statistics in Medicine·Chi Hyun LeeXianghua Luo
Dec 6, 2017·Statistics in Medicine·Tianmeng LyuChiung-Yu Huang
Mar 27, 2021·Lifetime Data Analysis·Chien-Lin SuIan Shrier

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