PMID: 7033099Jan 1, 1982Paper

Nonparenchymal cells cultivated from explants of fibrotic liver resemble endothelial and smooth muscle cells from blood vessel walls

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
B VossD B von Bassewitz

Abstract

Tissue specimens from human fibrotic liver obtained by needle biopsy were cultured. Two cell types emerged from the tissue explants. From their morphology and biosynthetic products they resembled smooth muscle cells and endothelial cells from blood vessel walls. In the "endothelial" cells, factor VIII-associated protein was demonstrated by indirect immunofluorescence. Synthesis of collagen types I and III, basement membrane collagen types IV and V, and fibronectin by both cell types was observed by immunofluorescence microscopy. Homogeneous cultures of "smooth muscle cells" were observed in subcultures. After incubation with [14C]glycine, collagen was isolated and characterized by CM cellulose chromatography, and consisted mainly of types I and III. These data suggest involvement of mesenchymal cells in hepatic fibrosis; they presumably originate from blood vessel or sinusoidal walls.

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Citations

Feb 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S L FriedmanG Yamasaki
Jan 1, 1987·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·A N Monteiro, R Borojevic
Aug 1, 1993·Digestive Diseases and Sciences·K YamaokaC Sato
Jul 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A N Monteiro, R Borojevic
May 1, 1992·Scandinavian Journal of Gastroenterology·F Blonde-CynoberL Cynober
Jul 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S MilaniH Stein
Feb 1, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Scott L Friedman, Meena B Bansal
Jan 1, 1985·Acta Medica Scandinavica. Supplementum·C S Lieber
Apr 1, 1990·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·R BorojevicH S Dutra
Jul 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M ChojkierM Filip
Nov 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C S Lieber
Nov 3, 2017·Journal of Gastroenterology·Linshan ShangDavid Allen Brenner
Jan 1, 1985·Acta Medica Scandinavica. Supplementum·V J Desmet
May 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A M de LeeuwD L Knook
Nov 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F B BianchiS Garbisa
Jan 1, 1985·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·G BallardiniF B Bianchi
Feb 1, 1995·In Vitro Cellular & Developmental Biology. Animal·A N Monteiro, R Borojevic
Jan 1, 1990·Pharmacology & Therapeutics·C S Lieber
May 2, 1986·Biochimica Et Biophysica Acta·P A MourãoR Borojevic

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