PMID: 16524353Mar 10, 2006

Nonparkinsonism movement disorders in the elderly

The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists
Jack J Chen, Kelly C Lee

Abstract

The primary objective of this article is to review the clinical presentation and pharmacologic management of essential tremor and tardive dyskinesia. The MEDLINE (1966-August 2005), Cochrane Database of Systematic Reviews, and International Pharmaceutical Abstracts (1970-August 2005) databases were searched for original research and review articles published in English. The search terms were essential tremor and tardive dyskinesia. Reference lists from articles were also consulted. Essential tremor is most commonly manifested as a postural or action tremor of the upper extremities. Midline regions such as the head and voice are also commonly affected. Based on review of the literature, propranolol and primidone are the current pharmacologic mainstays for treating essential tremor of the upper extremities. The choice of agent depends on patient-specific factors such as underlying medical conditions. Other agents with demonstrated efficacy include gabapentin and topiramate. Benzodiazepines are effective adjunctive agents, but should be utilized judiciously in the elderly. Botulinum toxin is effective for essential tremor of the voice and head. Surgery is very effective, but may not be appropriate in the frail elderly and should b...Continue Reading

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Citations

Jun 11, 2008·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Jeannette Y Wick, Guido R Zanni
Dec 11, 2008·Psychiatry and Clinical Neurosciences·Beatriz ArbaizarJavier Llorca

Related Concepts

Adrenergic beta-Antagonists
Anticonvulsants
Benzodiazepines
Differential Diagnosis
Dyskinesia, Medication-Induced
Etat Marbre
Vitamin E
Adrenergic Uptake Inhibitors
Familial Tremor

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