Nonpeptide neurotrophic agents useful in the treatment of neurodegenerative diseases such as Alzheimer's disease

Journal of Pharmacological Sciences
Masaaki AkagiReiko Akagi

Abstract

Developed regions, including Japan, have become "aged societies," and the number of adults with senile dementias, such as Alzheimer's disease (AD), Parkinson's disease, and Huntington's disease, has also increased in such regions. Neurotrophins (NTs) may play a role in the treatment of AD because endogenous neurotrophic factors (NFs) prevent neuronal death. However, peptidyl compounds have been unable to cross the blood-brain barrier in clinical studies. Thus, small molecules, which can mimic the functions of NFs, might be promising alternatives for the treatment of neurodegenerative diseases. Natural products, such as or nutraceuticals or those used in traditional medicine, can potentially be used to develop new therapeutic agents against neurodegenerative diseases. In this review, we introduced the neurotrophic activities of polyphenols honokiol and magnolol, which are the main constituents of Magnolia obovata Thunb, and methanol extracts from Zingiber purpureum (BANGLE), which may have potential therapeutic applications in various neurodegenerative disorders.

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Citations

Jul 26, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Hui JiangXianting Ding
Oct 16, 2016·The Journal of Organic Chemistry·José GomesKarl Gademann
Apr 21, 2018·The Journal of Pharmacology and Experimental Therapeutics·Soichi KawaharadaShuji Kaneko
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Aug 18, 2017·BioFactors·Sylwia TalarekSeyed Mohammad Nabavi
Jul 10, 2020·Journal of Natural Medicines·Yoshiyasu FukuyamaKenichi Harada
Mar 31, 2021·Journal of Microbiology and Biotechnology·Yong Sub ShinGun-Hee Kim
Jul 16, 2021·European Journal of Pharmacology·Kanandra Taisa Bertoncello, Carla Denise Bonan
Aug 17, 2021·Angewandte Chemie·Dongseok JangChulbom Lee

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