Nonphosphorylated high-molecular-weight neurofilament expression suggests early maturation of the monkey subiculum

Hippocampus
Pierre LavenexDavid G Amaral

Abstract

We analyzed the distribution of nonphosphorylated high-molecular-weight neurofilaments (NF-H) in the hippocampal formation of infant (3-week-old and 3-month-old) and adult (9-17-year-old) macaque monkeys in order to obtain neuroanatomical evidence of the maturity of these structures shortly after birth. We employed the monoclonal antibody SMI-32, a well-characterized antibody raised against nonphosphorylated NF-H, the expression of which is believed to reflect the maturation of certain neuronal populations. Patterns of SMI-32 immunoreactivity differed dramatically between infant and adult monkeys. In adults, nonphosphorylated NF-H expression was prominent in the CA3 and CA2 fields of the hippocampus, in the subiculum and in the entorhinal cortex. In infants, only the subiculum stained heavily for nonphosphorylated NF-H. These findings suggest that different subregions of the primate hippocampal formation mature at different times during development. The subiculum, the major source of efferent projections from the hippocampal formation toward subcortical structures, matures early during development. In contrast, the entorhinal cortex, the main interface of the hippocampal formation with the neocortex, matures relatively later. T...Continue Reading

References

Dec 15, 1978·The Journal of Comparative Neurology·D G Amaral
Jul 8, 1992·The Journal of Comparative Neurology·M J Beall, D A Lewis
May 15, 1991·The Journal of Comparative Neurology·M P Witter, D G Amaral
Feb 10, 1981·The Journal of Comparative Neurology·P Rakic, R S Nowakowski
Apr 1, 1996·The Journal of Comparative Neurology·S E Arnold, J Q Trojanowski
Apr 1, 1996·The Journal of Comparative Neurology·S E Arnold, J Q Trojanowski
Jan 1, 1996·Annual Review of Neuroscience·M K Lee, D W Cleveland
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·L R Squire, S M Zola
Apr 16, 1998·Neuron·B MilnerE R Kandel
Jul 14, 1998·Hippocampus·E Tulving, H J Markowitsch
Jul 14, 1998·Hippocampus·L R Squire, S M Zola
Jul 14, 1998·Hippocampus·M MishkinD G Gadian
Feb 18, 1999·Current Biology : CB·J Morris, R Lehmann
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·B A StrangeR J Dolan
Oct 12, 1999·The Journal of Comparative Neurology·J P Hornung, B M Riederer
Feb 25, 2000·Brain : a Journal of Neurology·D G GadianF Vargha-Khadem
Jan 3, 2001·The Journal of Comparative Neurology·P S Buckmaster, D G Amaral
Nov 24, 2001·Behavioural Brain Research·H Eichenbaum
Aug 27, 2002·Neuron·Neil BurgessJohn O'Keefe

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Citations

Feb 23, 2013·Behavioural Brain Research·Pierre Lavenex, Pamela Banta Lavenex
Dec 7, 2006·Developmental Neuroscience·Pierre LavenexDavid G Amaral
Oct 31, 2008·The Journal of Comparative Neurology·Pierre LavenexDavid G Amaral
Jul 30, 2011·The Journal of Comparative Neurology·Kevin R DuffyEmily E LeDue
Feb 24, 2011·The Journal of Comparative Neurology·Adeline JabèsPierre Lavenex
Jan 16, 2010·The European Journal of Neuroscience·Adeline JabèsPierre Lavenex
Jul 14, 2018·The Journal of Comparative Neurology·Olivia PiguetPierre Lavenex
Mar 7, 2020·The Journal of Comparative Neurology·Olivia PiguetPierre Lavenex
Mar 29, 2021·Developmental Cognitive Neuroscience·Kelsey L CanadaTracy Riggins

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