Nonplatinum-based chemotherapy with irinotecan plus docetaxel for advanced or metastatic olfactory neuroblastoma: a retrospective analysis of 12 cases

Cancer
Naomi KiyotaAtsushi Ohtsu

Abstract

The efficacy and safety of chemotherapy with irinotecan plus docetaxel were retrospectively evaluated for olfactory neuroblastoma. Twelve patients with histologically proven advanced or metastatic olfactory neuroblastoma were treated with chemotherapy with irinotecan plus docetaxel at the study institution between 2001 and 2005. Of these, 7 patients with locoregional disease and no prior radiotherapy received irinotecan plus docetaxel followed by definitive radiotherapy, 1 with photon radiotherapy and 6 with proton radiotherapy, whereas 3 patients with distant metastases and 2 with locoregional disease who had received prior radiotherapy received irinotecan plus docetaxel only. The most common toxicities of >or=grade 3 among the 12 patients receiving irinotecan plus docetaxel were leukopenia (33%), neutropenia (50%), febrile neutropenia (8%), and diarrhea (25%), all of which were manageable. Partial response was achieved in 3 patients, giving an overall response rate of 25%. The response rate was higher in patients aged <50 years (3 of 4 patients) compared with those aged >50 years (0 of 8 patients) (P = .018). With a median follow-up period of 22.2 months, the median progression-free survival and overall survival were 13.6 mon...Continue Reading

References

Sep 1, 1979·Cancer·D ElkonW C Constable
Aug 1, 1992·The Laryngoscope·P Dulguerov, T Calcaterra
Sep 1, 1992·Archives of Otolaryngology--head & Neck Surgery·W J RichtsmeierB S Carson
Apr 1, 1990·American Journal of Clinical Oncology·H G Goldsweig, N Sundaresan
Nov 1, 1990·The Laryngoscope·H F BillerP Som
Sep 1, 1988·International Journal of Radiation Oncology, Biology, Physics·C A SpauldingF M Stewart
Jan 1, 1981·Cancer·A B MillerA Winkler
Nov 15, 1993·International Journal of Radiation Oncology, Biology, Physics·R L FooteW M O'Fallon
May 1, 1993·Neurosurgery·A MoritaL M Quast
Oct 16, 1999·The Laryngoscope·P A LevineR W Cantrell
Jun 20, 2000·Acta Oncologica·J G EriksenK E Joergensen
Aug 15, 2000·Head & Neck·V A RestoW H Westra
Feb 27, 2001·The Laryngoscope·J H SimonJ M Buatti
Aug 16, 2001·Head & Neck·K S ChaoM Arquette
Mar 21, 2002·The Lancet Oncology·P DulguerovT C Calcaterra
Jan 22, 1955·Journal of the American Medical Association·L J McCORMACK, H E HARRIS
Jan 18, 2005·Head & Neck·Eduardo M DiazFranco DeMonte
Apr 3, 2007·International Journal of Radiation Oncology, Biology, Physics·Hideki NishimuraTeiji Nishio

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Citations

Jun 10, 2009·Oral and Maxillofacial Surgery·Nikolaos PapadogeorgakisConstantinos Alexandridis
Jul 31, 2013·Head & Face Medicine·Sajid AnsariMd Farid Amanullah
Mar 30, 2010·Journal of Neurosurgery·Ari J KaneAndrew T Parsa
Nov 3, 2012·Hematology/oncology Clinics of North America·Matthew Bak, Richard O Wein
Oct 18, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Guillaume De BonnecazeS Vergez
Oct 8, 2011·Otolaryngologic Clinics of North America·Richard J HarveyValerie Lund
May 16, 2009·The Laryngoscope·Anand K Devaiah, Michael T Andreoli
May 15, 2018·Head & Neck·John P MarinelliAshish V Chintakuntlawar
Jul 27, 2021·Journal of Neurological Surgery. Part B, Skull Base·Kevin C MillerJamie J Van Gompel

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