PMID: 10516029Oct 9, 1999Paper

Nonrandom distribution of hepatitis C virus quasispecies in plasma and peripheral blood mononuclear cell subsets

Journal of Virology
A M Roque AfonsoCyrille Feray

Abstract

The existence of an extrahepatic reservoir of hepatitis C virus (HCV) is suggested by differences in quasispecies composition between the liver, peripheral blood mononuclear cells, and serum. We studied HCV RNA compartmentalization in the plasma of nine patients, in CD19(+), CD8(+), and CD4(+) positively selected cells, and also in the negatively selected cell fraction (NF). HCV RNA was detected in all plasma samples, in seven of nine CD19(+), three of eight CD8(+), and one of nine CD4(+) cell samples, and in seven of eight NF cells. Cloning and sequencing of HVR1 in two patients showed a sequence grouping: quasispecies from a given compartment (all studied compartments for one patient and CD8(+) and NF for the other) were statistically more genetically like each other than like quasispecies from any other compartment. The characteristics of amino acid and nucleotide substitutions suggested the same structural constraints on HVR1, even in very divergent strains from the cellular compartments, and homogeneous selection pressure on the different compartments. These findings demonstrate the compartmental distribution of HCV quasispecies within peripheral blood cell subsets and have important implications for the study of extrahepa...Continue Reading

References

Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A J WeinerK A Crawford
Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·Y K ShimizuH Yoshikura
Feb 28, 1991·Biochemical and Biophysical Research Communications·M HijikataK Shimotohno
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R H Miller, R H Purcell
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·P FarciR H Purcell
Apr 1, 1993·The Journal of General Virology·H M MüllerL Theilmann
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·Y K ShimizuH Yoshikura
Feb 1, 1996·The Journal of Clinical Investigation·H LeratG Inchauspé
Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·P FarciR H Purcell
May 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A ZibertM Roggendorf
Oct 30, 1998·Science·P PileriS Abrignani
Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M OkudaK Okita
Dec 31, 1998·Gastroenterology·M ChenD R Milich

❮ Previous
Next ❯

Citations

Feb 5, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Daniel M FortonSimon D Taylor-Robinson
May 5, 2004·Proceedings of the National Academy of Sciences of the United States of America·Emmanuel G CormierTatjana Dragic
Oct 4, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Geoffrey W McCaughanHugo E Vargas
Mar 9, 2007·Orvosi hetilap·Gabriella LengyelZsolt Tulassay
Oct 16, 2004·Expert Review of Anti-infective Therapy·David DurantelFabien Zoulim
Aug 19, 2007·Digestive Diseases and Sciences·William PerryTarek I Hassanein
Oct 18, 2005·AIDS·Aurélie BriatMarianne Leruez-Ville
Oct 16, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rodolphe SobeskyValérie Thiers
Dec 16, 2011·Journal of Medical Virology·Jason T BlackardDenise J Jamieson
Aug 25, 2001·FEMS Microbiology Letters·R B Ray, R Ray
Sep 28, 2002·FEMS Microbiology Letters·M P H Stumpf, O G Pybus
Aug 11, 2004·The Journal of General Virology·Séverine DeforgesPatrice André
Jun 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jason T BlackardKenneth E Sherman
Mar 26, 2003·Cell Death and Differentiation·C Giannini, C Bréchot
Sep 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Emmanuel G CormierTatjana Dragic
Aug 19, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Huub C GelderblomPeter L M Jansen
Nov 3, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robin C HilsabeckCharles H Hinkin
Aug 11, 2004·The Journal of General Virology·James R JacobKeith G Mansfield
Oct 18, 2008·The Journal of Infectious Diseases·Frédéric SchrammEvelyne Schvoerer
Oct 16, 2015·Journal of Viral Hepatitis·A R RajalakshmyH N Madhavan
Mar 5, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Delphine DucoulombierCyrille Féray
Aug 20, 2002·The Journal of General Virology·Leandro Roberto JonesE Laura Weber
Aug 16, 2001·Journal of Medical Virology·C Caussin-SchwemlingF Stoll-Keller
May 8, 2007·European Journal of Epidemiology·Arleta Kowala-PiaskowskaWojciech Słuzewski
Mar 16, 2006·European Journal of Gastroenterology & Hepatology·Daniel M FortonHoward C Thomas
Apr 29, 2005·Journal of Virology·Anne-Marie Roque-AfonsoCyrille Féray
May 24, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Giorgio AntonucciUNKNOWN Italian Cohort Naive for Antiretrovirals Study Group
Jan 14, 2004·The Journal of General Virology·Victoria AlfonsoRodolfo Héctor Campos
Sep 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C SarrazinS Zeuzem
Oct 31, 2009·World Journal of Hepatology·Patricia Baré
Mar 5, 2003·Journal of Viral Hepatitis·D M FortonH C Thomas
Jan 17, 2002·Viral Immunology·Z Q YaoY S Hahn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.