Nonrandom HIV-1 infection and double infection via direct and cell-mediated pathways

Proceedings of the National Academy of Sciences of the United States of America
Que DangWei-Shau Hu

Abstract

Cells infected with two related retroviruses can generate heterozygous virions, which are the precursors of recombinant proviruses. Although many studies have focused on the frequencies and mechanisms of retroviral recombination, little is known about the dynamics of double infection. To examine this issue, viruses generated from two HIV-1 vectors containing different markers were mixed together, and were used to infect target cells. The numbers of cells expressing none, one, or both markers were measured and were used to calculate whether double infection occurred at frequencies expected from random infection events. We found that double infection occurred significantly more frequently than predicted from random distribution; increased rates of double infection were observed in both a T cell line and primary activated CD4(+) T cells. In addition to direct virus infection, we also examined the nature of cell-mediated HIV-1 double infection. Increased double infection was observed in all experiments regardless of whether a cell line or primary human dendritic cells were used for capture and transmission of HIV-1. Therefore, our results indicate that HIV-1 double infection occurs more frequently than it would at random in both di...Continue Reading

References

Aug 1, 1975·Journal of Virology·H J KungR M McAllister
Nov 1, 1992·AIDS Research and Human Retroviruses·F E McCutchanD S Burke
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·W S Hu, H M Temin
Mar 1, 1989·Journal of Virology·F ClavelR Repaske
Jan 1, 1987·Molecular and Cellular Biology·R B DuBridgeM P Calos
Aug 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·P H Duesberg
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·W S PearD Baltimore
Mar 9, 1995·Nature·M T Nakamura
Mar 9, 1995·Nature·D L RobertsonB H Hahn
Jun 1, 1997·The Journal of Clinical Investigation·D D Ho
Aug 1, 1997·Current Opinion in Immunology·G Grouard, E A Clark
Jun 25, 1998·Revue Scientifique Et Technique·J P Stoye
Jun 8, 1999·The Journal of Experimental Medicine·D UnutmazD R Littman
Jan 11, 2000·Journal of Virology·A E JetztJ P Dougherty
Oct 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·C K HwangV K Pathak
Apr 3, 2002·The Journal of Experimental Medicine·Alison MotsingerDerya Unutmaz
Jul 12, 2002·Nature·Andreas JungAndreas Meyerhans
May 6, 2003·Science·David McDonaldThomas J Hope
Jun 26, 2003·Trends in Microbiology·Paul D Bieniasz
Jul 2, 2003·Nature Medicine·Norman L Letvin, Bruce D Walker

❮ Previous
Next ❯

Citations

May 21, 2004·Nature Reviews. Microbiology·Jean-Christophe PaillartJohnson Mak
Dec 13, 2005·Sexual Health·Megan C SteainNitin K Saksena
Jun 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Lina JosefssonSarah E Palmer
Aug 2, 2007·Proceedings. Biological Sciences·Dominik Wodarz, David N Levy
Jul 15, 2011·Science Translational Medicine·Alan S Perelson, Steven G Deeks
May 6, 2011·Journal of Virology·Armando Del PortilloBenjamin K Chen
Jun 15, 2012·Journal of Virology·Christelle BrégnardStéphane Basmaciogullari
Jul 29, 2004·Journal of Virology·Narendra M Dixit, Alan S Perelson
Sep 2, 2009·Microbiology and Molecular Biology Reviews : MMBR·Adewunmi Onafuwa-Nuga, Alice Telesnitsky
Jul 11, 2008·Retrovirology·Huub C GelderblomDavid N Levy
May 10, 2012·Biology Direct·Kara W CummingsDominik Wodarz
Oct 31, 2007·PLoS Computational Biology·Gajendra W Suryavanshi, Narendra M Dixit
May 6, 2010·PLoS Computational Biology·Timothy E SchlubMiles P Davenport
Oct 14, 2011·Viruses·Krista Delviks-FrankenberryWei-Shau Hu
Jun 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Narendra M Dixit, Alan S Perelson
Sep 26, 2014·Viruses·Jonathan M O Rawson, Louis M Mansky
Apr 10, 2013·Journal of Theoretical Biology·Elena E GiorgiTanmoy Bhattacharya
Jun 26, 2012·Virus Research·Redmond P SmythJohnson Mak
Nov 26, 2009·Mathematical Biosciences·Isaac Chun-Hai FungGeoffrey P Garnett
Dec 17, 2014·Journal of Theoretical Biology·John Wei LauDominik Wodarz
Jun 3, 2009·Evolution; International Journal of Organic Evolution·Dominik Wodarz, David N Levy
Feb 1, 2009·Evolutionary Applications·Sarah B JosephChristina L Burch
Jan 15, 2005·Virus Research·Robert A SmithBradley D Preston
Aug 28, 2012·Current Opinion in Virology·Serafín GutiérrezStéphane Blanc
Apr 25, 2015·Journal of Theoretical Biology·Ani AsatryanNatalia L Komarova
Mar 15, 2015·Mathematical Biosciences·Dustin Phan, Dominik Wodarz

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