PMID: 8948341Oct 1, 1996Paper

Nonrandomized evaluation of pelvic lymph node irradiation in localized carcinoma of the prostate

International Journal of Radiation Oncology, Biology, Physics
C A PerezM A Lockett

Abstract

A great deal of controversy exists regarding the potential benefit of pelvic lymph node irradiation compared with treatment to the prostate only in patients with localized prostate cancer. Despite numerous reports, including a randomized study, this issue has not been completely elucidated. A total of 963 patients with histologically proven localized adenocarcinoma of the prostate treated with definitive radiation therapy alone were analyzed. Median follow-up was 6.5 years (minimum: 2 years, maximum: 22 years). Pelvic lymph nodes received 40 to 55 Gy with anteroposterior/posteroanterior and sometimes lateral stationary portals in 1.8 Gy daily fractions; an additional dose was delivered to the prostate with 120 degrees bilateral are rotation to complete doses of 65 to 68 Gy for Stage A2 and B tumors and 68 to 71 Gy for Stage C tumors. The same total doses were delivered with smaller fields when the prostate only was treated. In Stage A2 (T1b,c) the 10-year clinical pelvic failure rate was 16% regardless of the volume irradiated or tumor differentiation. With Stage B (T2) well- or moderately differentiated tumors, the 10-year pelvic failure rates were 22% when pelvic lymph nodes were irradiated and 32% when prostate only was irra...Continue Reading

References

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Citations

Sep 3, 2013·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·O ChapetF Lorchel
Oct 6, 2000·International Journal of Radiation Oncology, Biology, Physics·C M NuttingD P Dearnaley
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