PMID: 2111852May 1, 1990Paper

Nonrandomness in prebiotic peptide synthesis

Journal of Molecular Evolution
S Tyagi, C Ponnamperuma

Abstract

We have synthesized and studied the properties of phosphoanhydrides of alanine with guanosine monophosphate, uridine monophosphate, and adenosine monophosphate. This series of compounds allowed us to investigate the specificity of peptide bound formation in a reaction that could have taken place on the prebiotic earth. We asked whether the intrinsic reactivity of the amino acids, the nature of the nucleotide in the anhydride, or the complementary polynucleotide template influences the specificity of the peptide synthesis reaction. We observed that the differential reactivity of the amino acids results in nearest-neighbor preferences during the peptide synthesis, whereas the nature of the nucleotides and the presence of complementary polynucleotides had no influence on the specificity. These results suggest that some peptides would have been more abundant than others on the prebiotic earth and have implications for the study of the origins of the genetic code and protein synthesis.

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Citations

Jan 1, 1993·Chirality·N S Wickramasinghe, J C Lacey
Jan 11, 1992·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·J C LaceyG W Cook
Dec 9, 2003·Journal of Biosciences·Subramania RanganathanS D Vudayagiri
Oct 8, 1997·Journal of Molecular Evolution·S Alberti
May 30, 2013·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·J Dennis PollackDennis K Pearl
Mar 1, 1995·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·C PonnamperumaY Honda
Mar 1, 1995·Geochimica Et Cosmochimica Acta·S W Fox
Jan 8, 2008·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·M RamalingamJ Swaminathan
Mar 19, 1991·Biochemistry·N S WickramasingheJ C Lacey
Jun 15, 2007·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Robert Root-Bernstein
Feb 27, 2020·Chemical Reviews·Moran Frenkel-PinterLuke J Leman

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