Nonredundant roles for hippocampal and entorhinal cortical plasticity in spatial memory storage

Pharmacology, Biochemistry, and Behavior
April E Hebert, Pramod K Dash

Abstract

Recently, it has been demonstrated that targeted blockade of the extracellular signal-regulated kinase (ERK) cascade in either the entorhinal cortex (EC) or hippocampus (HIP) results in spatial memory deficits. However, it is unclear if ERK-mediated plasticity in these structures has redundant functions or unique roles. In this report, we contrast the role of long-term plasticity in these two structures with side-by-side comparisons of the effects of PD098059 infusion following water maze training. Analysis of performance during the long-term retention test indicates a role for plasticity in the EC in storing broad location information. In contrast, blocking plasticity in the HIP resulted in deficits in indices of precise location information and goal-directed navigational error. To distinguish between a navigational and location deficit, a "two-room" experimental design was employed. Training in the first room allowed animals to consolidate information regarding navigational strategies prior to training and drug infusion in the second room. Hippocampal-PD098059-infused animals demonstrated behavior suggestive of an expanded representation of the platform location and, thus, a loss of precise location information, suggesting th...Continue Reading

Citations

Dec 27, 2008·Neurobiology of Learning and Memory·Frédéric ChauveauDaniel Béracochéa
Jan 24, 2014·Oxidative Medicine and Cellular Longevity·Chatchada SutalangkaWipawee Thukham-mee
Nov 16, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Amy E ClippertonElena Choleris
Nov 5, 2005·Risk Analysis : an Official Publication of the Society for Risk Analysis·Rob P Rechard, Martin S Tierney
Aug 11, 2007·Memory & Cognition·S E Avons
Aug 13, 2020·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Jennifer L ThompsonSteven Paul Woods
Oct 14, 2020·Perspectives on Psychological Science : a Journal of the Association for Psychological Science·Corentin Gonthier

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