Nonredundant roles for leukotriene B4 receptors BLT1 and BLT2 in inflammatory arthritis

The Journal of Immunology : Official Journal of the American Association of Immunologists
Steven MathisB Haribabu

Abstract

Lipid mediators derived from arachidonic acid through the cyclooxygenase and lipoxygenase pathways are known to be important mediators of inflammation. Studies in mouse models demonstrated an important role for the high-affinity leukotriene B(4) receptor BLT1 in arthritis, atherosclerosis, and asthma. BLT2, a low-affinity leukotriene B(4) receptor, was also shown to be a high-affinity receptor for cyclooxygenase-1 derived 12(S)-hydroxyheptadeca-5Z, 8E, 10E-trienoic acid. However, its biochemical activities and physiological roles remain unknown. In this study, we developed mice deficient in BLT2 by targeted disruption. The BLT2(-/-) mice developed normally, and analysis of immune cells showed that disruption of BLT2 did not alter BLT1 expression or function. Mast cells from the C57BL/6 mice but not from the BLT2(-/-) mice showed intracellular calcium mobilization in response to 12(S)-hydroxyheptadeca-5Z, 8E, 10E-trienoic acid. In an autoantibody-induced inflammatory arthritis model, the BLT2(-/-) mice showed reduced incidence and severity of disease, including protection from bone and cartilage loss. Reciprocal bone marrow transplant experiments identified that loss of BLT2 expression on a bone marrow-derived cell lineage offer...Continue Reading

References

Jan 1, 1989·Scandinavian Journal of Rheumatology·J J BelchR D Sturrock
Oct 1, 1984·The Journal of Clinical Investigation·M A GimbroneA I Schafer
Jan 17, 1995·Proceedings of the National Academy of Sciences of the United States of America·R J GriffithsA J Milici
Nov 29, 1996·Cell·V KouskoffD Mathis
Mar 17, 1997·The Journal of Experimental Medicine·R J GriffithsJ D McNeish
Jul 13, 2000·The Journal of Biological Chemistry·M KamoharaK Furuichi
Mar 30, 2001·The Journal of Biological Chemistry·T YokomizoT Shimizu
Nov 7, 2001·The American Journal of Pathology·A R PettitE M Gravallese
Nov 16, 2002·Prostaglandins & Other Lipid Mediators·Akiko TodaTakao Shimizu
Aug 5, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Andrew M Tager, Andrew D Luster
Sep 2, 2003·Nature Immunology·Andrew M TagerAndrew D Luster
Dec 6, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Krishnaprasad SubbaraoBodduluri Haribabu
Nov 25, 2004·The Journal of Biological Chemistry·Venkatakrishna R JalaBodduluri Haribabu
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nobuaki MiyaharaErwin W Gelfand
Apr 26, 2005·American Journal of Respiratory and Critical Care Medicine·Nobuaki MiyaharaErwin W Gelfand
Mar 29, 2006·The Journal of Experimental Medicine·Nancy D KimAndrew D Luster
Mar 29, 2006·The Journal of Experimental Medicine·Mei ChenDavid M Lee
Apr 21, 2006·Proceedings of the National Academy of Sciences of the United States of America·Hong QiuJesper Z Haeggström
May 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wen-Hai ShaoBodduluri Haribabu
Aug 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katherine A LundeenAnne M Fourie
Dec 16, 2006·Annals of the Rheumatic Diseases·Federico Díaz-GonzálezStephen H Polmar
Oct 31, 2007·Autoimmunity Reviews·Steven MathisBodduluri Haribabu
Apr 2, 2008·The Journal of Experimental Medicine·Toshiaki OkunoTakao Shimizu
Mar 3, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Geun-Young KimJae-Hong Kim

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Citations

Jul 24, 2012·Analytical Chemistry·Donghyuk Kim, Christy L Haynes
Jul 13, 2011·Journal of Biochemistry·Makoto MurakamiKei Yamamoto
Nov 8, 2011·Journal of Leukocyte Biology·Christian D Sadik, Andrew D Luster
Jun 25, 2015·Proceedings of the National Academy of Sciences of the United States of America·Anne-Claire DuchezEric Boilard
Jul 19, 2013·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Rakesh Kumar SinghAbhijit Ray
Dec 3, 2014·Arthritis Research & Therapy·Neha DixitIannis E Adamopoulos
Apr 5, 2014·BioMed Research International·Mariana Trivilin Mendes, Paulo Flavio Silveira
May 27, 2017·Journal of Lipid Research·Ann V HertzelDavid A Bernlohr
Feb 6, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fernando P ConteMaria G Henriques
Apr 30, 2015·Nature Communications·Shuchismita R SatpathyBodduluri Haribabu
May 19, 2011·Current Opinion in Clinical Nutrition and Metabolic Care·Marcos Martínez-ClementeEsther Titos
Jan 18, 2014·Experimental Dermatology·Christian D SadikNancy D Kim
Mar 7, 2014·Modern Rheumatology·Bahman YousefiAbbas Mirshafiey
Mar 5, 2014·British Journal of Pharmacology·Magnus BäckG Enrico Rovati
Mar 1, 2017·The Journal of Biological Chemistry·Sebastian ZinnKlaus Scholich
Jan 8, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kinsey A HilliardCharles R Brown
Jan 29, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Victoria A BlahoCharles R Brown
Jul 12, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthew SpiteBodduluri Haribabu
Jun 18, 2017·Biological Chemistry·Julia Esser-von Bieren
Feb 14, 2015·Journal of Anatomy·Ann Kristin HansenBaldur Sveinbjörnsson
Jul 29, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zinal S ChhedaBodduluri Haribabu
Jan 6, 2017·Journal of Lipid Research·Yan ZhangCharles R Brown
Jul 25, 2019·International Journal of Molecular Sciences·Airi Jo-WatanabeTakehiko Yokomizo
Aug 21, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rajesh Kumar SharmaBodduluri Haribabu
Mar 27, 2013·Modern Rheumatology·Bahman YousefiAbbas Mirshafiey
May 27, 2017·Journal of Cardiothoracic Surgery·Zheng-Liang TuJian Hu
Nov 15, 2019·The Korean Journal of Internal Medicine·Hong Ki MinHae-Rim Kim
Oct 3, 2020·Mediators of Inflammation·Yanting CaoYiqing Yin
Jun 15, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Toshiaki HirakataTakehiko Yokomizo
Sep 19, 2020·Journal of Medicinal Chemistry·Victor Hernandez-OlmosEwgenij Proschak
Apr 30, 2011·Chemical Reviews·Motonao Nakamura, Takao Shimizu
Sep 23, 2011·Chemical Reviews·Jesper Z Haeggström, Colin D Funk

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