Nonredundant Roles of Interleukin-17A (IL-17A) and IL-22 in Murine Host Defense against Cutaneous and Hematogenous Infection Due to Methicillin-Resistant Staphylococcus aureus

Infection and Immunity
Liana C ChanMichael R Yeaman

Abstract

Staphylococcus aureus is the leading cause of skin and skin structure infections (SSSI) in humans. Moreover, the high frequency of recurring SSSI due to S. aureus, particularly methicillin-resistant S. aureus (MRSA) strains, suggests that infection induces suboptimal anamnestic defenses. The present study addresses the hypothesis that interleukin-17A (IL-17A) and IL-22 play distinct roles in immunity to cutaneous and invasive MRSA infection in a mouse model of SSSI. Mice were treated with specific neutralizing antibodies against IL-17A and/or IL-22 and infected with MRSA, after which the severity of infection and host immune response were determined. Neutralization of either IL-17A or IL-22 reduced T cell and neutrophil infiltration and host defense peptide elaboration in lesions. These events corresponded with increased abscess severity, MRSA viability, and CFU density in skin. Interestingly, combined inhibition of IL-17A and IL-22 did not worsen abscesses but did increase gamma interferon (IFN-γ) expression at these sites. The inhibition of IL-22 led to a reduction in IL-17A expression, but not vice versa. These results suggest that the expression of IL-17A is at least partially dependent on IL-22 in this model. Inhibition of...Continue Reading

References

Jan 1, 1988·Journal of General Microbiology·S W EdwardsV Hughes
Jul 1, 1993·The Journal of Infectious Diseases·D W BrarR A Proctor
Jan 24, 2003·Infection and Immunity·Jagath L KadurugamuwaPamela R Contag
Apr 21, 2004·Immunology·Terri N Ellis, Blaine L Beaman
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hilmar WisplinghoffMichael B Edmond
Aug 17, 2004·Immunity·Kerstin WolkRobert Sabat
Dec 13, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Evan J AndersonFrank J Palella
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dean ToyJacques Peschon
Sep 20, 2006·The Journal of Experimental Medicine·Spencer C LiangLynette A Fouser
Feb 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susan M SaWenjun Ouyang
Jul 10, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cristina AlbanesiMichael D Howell
Oct 18, 2007·JAMA : the Journal of the American Medical Association·R Monina KlevensUNKNOWN Active Bacterial Core surveillance (ABCs) MRSA Investigators
Oct 22, 2008·International Archives of Medicine·Dongxia Ge, Zongbing You
Feb 26, 2009·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Paul KingStephen Holdsworth
Oct 7, 2009·The Journal of Clinical Investigation·Kent DoiRobert A Star
Nov 19, 2009·The Journal of Clinical Investigation·Stefanie EyerichAndrea Cavani
Feb 4, 2010·Seminars in Immunopathology·Kerstin WolkRobert Sabat
Feb 12, 2010·Annals of the New York Academy of Sciences·Jesse M DamskerRachel R Caspi
Mar 9, 2010·Lancet·Frank R DeLeoHenry F Chambers
Apr 7, 2010·The Journal of Clinical Investigation·John S ChoLloyd S Miller
Sep 3, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Helen BoucherRaymund R Razonable
Oct 12, 2010·The Journal of Antimicrobial Chemotherapy·Matthew S Dryden
Oct 15, 2010·The Journal of Investigative Dermatology·Kerstin AhrensEhrhardt Proksch
Dec 15, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kerstin WolkRobert Sabat
Mar 1, 2011·Trends in Microbiology·Alice G ChengDominique Missiakas
Jun 1, 2011·Clinical and Molecular Allergy : CMA·Eunkyung SongGuha Krishnaswamy
Jul 2, 2011·Nature Reviews. Immunology·Lloyd S Miller, John S Cho
Oct 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Frank R DeLeoBarry N Kreiswirth
Apr 12, 2012·Clinical Microbiology Reviews·Sebastian J van HalIain B Gosbell
Apr 12, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christine Selton-SutyUNKNOWN AEPEI Study Group
Jun 7, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pierre TattevinBinh An Diep
Jul 5, 2012·JAMA : the Journal of the American Medical Association·Michael L LandrumClinton K Murray

❮ Previous
Next ❯

Citations

Oct 22, 2016·Trends in Microbiology·Michelle E Mulcahy, Rachel M McLoughlin
Jan 8, 2017·Annual Review of Pharmacology and Toxicology·Michael R Yeaman, John P Hennessey
Apr 8, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Krystle A BlanchetteJoseph C Wenke
Feb 25, 2018·Proceedings of the National Academy of Sciences of the United States of America·Lloyd S Miller, Scott I Simon
Feb 9, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·John M LeechRachel M McLoughlin
Feb 6, 2018·The Journal of Clinical Investigation·Carly A DillenLloyd S Miller
Jul 13, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria-Luisa AlegreRobert S Daum
Jul 18, 2017·F1000Research·Shibali Das, Shabaana Khader
Aug 8, 2017·Science Immunology·Sandip K Datta
Oct 7, 2018·Archivum Immunologiae Et Therapiae Experimentalis·Bartłomiej WawrzyckiJacek Roliński
May 16, 2019·Proceedings of the National Academy of Sciences of the United States of America·Mark C MarchittoLloyd S Miller
Jul 9, 2020·Frontiers in Cellular and Infection Microbiology·Danielle Ahn, Alice Prince
Oct 10, 2018·Proceedings of the National Academy of Sciences of the United States of America·Liana C ChanUNKNOWN MRSA Systems Immunobiology Group
Feb 23, 2020·Clinical & Translational Immunology·Yi CaoCarrie M Rosenberger
Nov 21, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Partha S Biswas
Apr 17, 2019·Current Dermatology Reports·Qi LiuLloyd S Miller
Nov 13, 2020·Frontiers in Immunology·Min YangJintong Tan
Apr 1, 2021·The Australasian Journal of Dermatology·Tulin ErgunHaner Direskeneli
Dec 2, 2020·The Journal of Allergy and Clinical Immunology·Raquel Castillo-GonzálezFrancisco Sánchez-Madrid

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Cellulitis

Cellulitis (erysipelas) is a recurring and debilitating bacterial infection of the skin and underlying tissue. Discover the latest research on cellulitis here.

CRISPR & Staphylococcus

CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.