Nonrespiratory predictor of mechanical ventilation dependency in intensive care unit patients

Critical Care Medicine
M J SapijaszkoY Berthiaume

Abstract

To determine the role of serum albumin concentration as a predictor of mechanical ventilation dependency. Prospective, observation trial. Multidisciplinary intensive care unit (ICU) in a university hospital. One hundred forty-five consecutive patients who required mechanical ventilation for > 72 hrs. Patients were classified into five different groups based on the cause of respiratory failure. The following parameters were recorded daily: serum albumin concentration; Acute Physiology and Chronic Health Evaluation II (APACHE II) score; and fluid balance. Using multiple regression, multiple logistic regression analysis, and the Anderson-Gill proportional hazards model, we determined the metabolic factors that could help predict weaning success. The mean length of ICU stay was 12.3 +/- 1.0 days. The duration of mechanical ventilation dependency was 10.5 +/- 1.0 days. The initial mean serum albumin concentration was 25.2 +/- 0.6 g/L. The APACHE II score on the first day of ICU stay was 19.1 +/- 0.6. Although albumin concentration was significantly lower and the APACHE II score was significantly higher in ICU nonsurvivors than in ICU survivors, albumin concentration on ICU admission was not a predictor of the length of time spent re...Continue Reading

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