Nonselective beta-blockers in cirrhotic patients with no or small varices: A meta-analysis

World Journal of Gastroenterology : WJG
Xingshun QiXiaozhong Guo

Abstract

To explore effects of nonselective beta-blockers (NSBBs) in cirrhotic patients with no or small varices. The PubMed, EMBASE, Science Direct, and Cochrane library databases were searched for relevant papers. A meta-analysis was performed using ORs with 95%CI as the effect sizes. Subgroup analysis was conducted according to the studies including patients without varices and those with small varices. Overall, 784 papers were initially retrieved from the database searches, of which six randomized controlled trials were included in the meta-analysis. The incidences of large varices development (OR = 1.05, 95%CI: 0.25-4.36; P = 0.95), first upper gastrointestinal bleeding (OR = 0.59, 95%CI: 0.24-1.47; P = 0.26), and death (OR = 0.70, 95%CI: 0.45-1.10; P = 0.12) were similar between NSBB and placebo groups. However, the incidence of adverse events was significantly higher in the NSBB group compared with the placebo group (OR = 3.47, 95%CI: 1.45-8.33; P = 0.005). The results of subgroup analyses were similar to those of overall analyses. The results of this meta-analysis indicate that NSBBs should not be recommended for cirrhotic patients with no or small varices.

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Citations

Sep 2, 2015·Expert Review of Gastroenterology & Hepatology·Xingshun QiXiaozhong Guo
Oct 9, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Mattias Mandorfer, Thomas Reiberger
Jan 12, 2017·BMJ Open Gastroenterology·Sara Blasco-AlgoraConrado Fernández-Rodriguez
Sep 13, 2017·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Irakoze LaurentQi Fu Li
Jan 11, 2020·Clinical and Molecular Hepatology·UNKNOWN Korean Association for the Study of the Liver (KASL)
Jan 31, 2019·World Journal of Gastrointestinal Pharmacology and Therapeutics·Umesha BoregowdaShreyas Saligram
Oct 11, 2020·Journal of Evidence-based Medicine·Dmitry Victorovich Garbuzenko, Nikolay Olegovich Arefyev
Mar 31, 2021·The Cochrane Database of Systematic Reviews·Maria Corina Plaz TorresKurinchi Selvan Gurusamy
Apr 7, 2021·The Cochrane Database of Systematic Reviews·Davide RoccarinaKurinchi Selvan Gurusamy
Apr 11, 2021·The Cochrane Database of Systematic Reviews·Danielle RobertsKurinchi Selvan Gurusamy
Apr 12, 2021·Clinics in Liver Disease·Mathias Jachs, Thomas Reiberger

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