Nonselective Compared With Selective α-Blockade Is Associated With Less Intraoperative Hypertension in Patients With Pheochromocytomas and Paragangliomas: A Retrospective Cohort Study With Propensity Score Matching.

Anesthesia and Analgesia
Hao KongDong-Xin Wang

Abstract

Both selective and nonselective α-blockade are used for preoperative preparation in patients with pheochromocytomas and paragangliomas (PPGLs). However, the effects of different types of α-blockade on perioperative outcomes remain inconclusive. This study was designed to assess the association between the choice of α-blockade and the amount of intraoperative hypertension in patients undergoing surgery for PPGLs. In this propensity-matched retrospective cohort study, data of patients who received either selective or nonselective α-blockade preoperatively and underwent surgery for PPGLs were collected. The primary end point was the time-weighted average above the systolic blood pressure (SBP) of 160 mm Hg (TWA-SBP >160 mm Hg), which was calculated as the total area of the SBP-time curve above the SBP of 160 mm Hg and divided by anesthesia duration. A total of 286 patients were included in analysis; of them, 156 received selective α-blockade and 130 nonselective α-blockade. After propensity score matching, 89 patients remained in each group. Patients who received nonselective α-blockade had a lower TWA-SBP >160 (median 0.472 mm Hg, interquartile range [IQR], 0.081-1.300) versus those who received selective α-blockade (median 1.114...Continue Reading

References

Jan 28, 1967·British Medical Journal·E J RossB J Harries
Jun 11, 1999·Annals of Surgery·R E GoldsteinH W Scott
Jun 26, 2001·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·M AritonT W AvRuskin
Aug 23, 2002·World Journal of Surgery·Cedric Prys-Roberts, John R Farndon
Jan 25, 2003·BMJ : British Medical Journal·Douglas G Altman, J Martin Bland
Nov 1, 1954·Anesthesiology·J E THOMPSON, J G ARROWOOD
Apr 15, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masao OmuraTetsuo Nishikawa
Aug 23, 2005·Lancet·Jacques W M LendersKarel Pacak
Dec 8, 2009·The Journal of Clinical Endocrinology and Metabolism·H BruynzeelG Kazemier
Jun 4, 2014·The Journal of Clinical Endocrinology and Metabolism·Jacques W M LendersWilliam F Young
Jun 19, 2014·Annals of Surgical Oncology·Colleen M KiernanCarmen C Solorzano
Mar 31, 2015·Annals of Surgical Oncology·Margaret LivingstoneJanice Pasieka
Aug 27, 2016·Annals of Surgical Oncology·Reese W RandleRebecca S Sippel
Feb 27, 2018·International Journal of Urology : Official Journal of the Japanese Urological Association·Ho Seok ChungDong Deuk Kwon
Nov 13, 2019·The Journal of Clinical Endocrinology and Metabolism·Edward BuitenwerfMichiel N Kerstens

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Citations

May 4, 2021·Current Opinion in Anaesthesiology·Claudia Fernandez-RoblesAdriana D Oprea
May 26, 2021·Anesthesia and Analgesia·Roman Schumann, Harald Thomas Groeben
May 26, 2021·Anesthesia and Analgesia·Hao KongDong-Xin Wang

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