PMID: 376093Apr 1, 1979Paper

Nonspecific immune determinants in the patient with unresectable gastrointestinal carcinoma

Cancer
C G MoertelA Silvers

Abstract

Assays of immune function (recall skin tests to microbial antigens; total circulating lymphocytes, T-cells, B-cells; lymphocyte blastogenesis with PHA, Con A, and pokeweed mitogens; and serum immunoglobulins IgA, IgM, IgG) were obtained in 408 patients with unresectable gastrointestinal carcinoma. The overall patient population, in comparison to normal controls, was characterized by reduced response to recall skin tests, reduced total lymphocyte and T-cell counts, reduced lymphocyte blastogenesis assays, increased B-cell counts and increased IgA and IgM. Significant immunosuppression was associated with prior radiation or chemotherapy, and with impaired patient performance status. There was no apparent correlation between extent of clinically evident malignant disease and immune function within this patient population. No assay of immune function matched the prognostic value of the more readily available and less expensive determinations of performance status, serum alkaline phosphatase, or SGOT. Only reactivity to recall skin tests had a significant correlation to patient survival independent of performance status. Among patients with little or no disability, only intensity of skin test reactivity correlated significantly with...Continue Reading

References

Jul 14, 1973·Lancet·R Hoover, J F Fraumeni
Sep 15, 1973·International Journal of Cancer. Journal International Du Cancer·J H KerseyR A Good

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Citations

Jan 1, 1986·Journal of Cancer Research and Clinical Oncology·M ZembalaH Labza
Nov 1, 1987·The American Journal of the Medical Sciences·J SaltzH F Seigler
May 1, 1985·Journal of Surgical Oncology·G SinghN N Khanna
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Jan 1, 1980·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·R E RyanR E Ritts

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