PMID: 22563780May 9, 2012Paper

Nonstandard drugs and feasible new interventions for autoimmune hepatitis: part II

Inflammation & Allergy Drug Targets
Albert J Czaja

Abstract

Molecular, cellular, and genetic interventions are now feasible for autoimmune hepatitis because of improved understanding of pathogenic mechanisms, advances in recombinant technology, and previous successes in animal models and humans with other immune-mediated inflammatory diseases. Non-mitogenic monoclonal antibodies to CD3 promote apoptosis of cytotoxic T lymphocytes, inhibit production of pro-inflammatory cytokines, improve the function of regulatory T cells, and induce a durable remission in mouse models and humans with autoimmune diabetes. Monoclonal antibodies to CD20 deplete B lymphocytes, modify antibody-dependent and cell-mediated cytotoxic pathways, enhance regulatory T cell function, and improve isolated cases of autoimmune hepatitis with B-cell disorders. Recombinant cytotoxic T lymphocyte antigen-4 fused with immunoglobulin can block the second co-stimulatory signal required for lymphocyte activation, and it has been licensed for use in rheumatoid arthritis but not tried in autoimmune hepatitis. Other considerations on the distant horizon are monoclonal antibodies against inhibitory receptors on regulatory T cells, adoptive transfer of fresh regulatory T cells, tailored glycolipids that strengthen the immunosuppr...Continue Reading

Citations

Oct 24, 2012·Digestive Diseases and Sciences·Albert J Czaja
Jan 12, 2013·Digestive Diseases and Sciences·Albert J Czaja
Jun 26, 2014·Expert Opinion on Pharmacotherapy·Albert J Czaja
Jan 7, 2014·Alimentary Pharmacology & Therapeutics·A J Czaja
Mar 19, 2014·Alimentary Pharmacology & Therapeutics·A J Czaja
Dec 5, 2013·Alimentary Pharmacology & Therapeutics·A J Czaja
Dec 10, 2014·Digestive Diseases and Sciences·Aldo J Montano-Loza, Albert J Czaja
Oct 16, 2012·Expert Review of Gastroenterology & Hepatology·Albert J Czaja
Oct 16, 2012·Expert Review of Gastroenterology & Hepatology·Albert J Czaja
Apr 14, 2017·Expert Review of Clinical Immunology·Albert J Czaja

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