Nonsteroidal anti-inflammatory drug, indomethacin improves spatial memory and NMDA receptor function in aged animals

Neurobiology of Aging
Ashok KumarT C Foster

Abstract

A redox-mediated decrease in N-methyl-D-aspartate (NMDA) receptor function contributes to psychiatric diseases and impaired cognition during aging. Inflammation provides a potential source of reactive oxygen species for inducing NMDA receptor hypofunction. The present study tested the hypothesis that the nonsteroidal anti-inflammatory drug indomethacin, which improves spatial episodic memory in aging rats, would enhance NMDA receptor function through a shift in the redox state. Male F344 young and aged rats were prescreened using a 1-day version of the water maze task. Animals were then treated with the indomethacin or vehicle, delivered in a frozen milk treat (orally, twice per day, 18 days), and retested on the water maze. Indomethacin treatment enhanced water maze performance. Hippocampal slices were prepared for examination of CA3-CA1 synaptic responses, long-term potentiation, and NMDA receptor-mediated synaptic responses. No effect of treatment was observed for the total synaptic response. Long-term potentiation magnitude and NMDA receptor input-output curves were enhanced for aged indomethacin-treated animals. To examine redox regulation of NMDA receptors, a second group of aged animals was treated with indomethacin or v...Continue Reading

References

Jul 1, 1994·British Journal of Clinical Pharmacology·P N Bruce-JonesL Kalra
Feb 1, 1997·Neuropharmacology·L HorákováL Derková
Apr 5, 2001·Journal of Neurophysiology·T C Foster, T C Dumas
Oct 24, 2002·Neurobiology of Aging·Andis Klegeris, Patrick L McGeer
Jan 14, 2003·European Journal of Pharmacology·Osamu MiyamotoToshifumi Itano
May 5, 2004·Neurobiology of Aging·Michael H MeschesPaula C Bickford
Jun 27, 2006·Neurobiology of Aging·Kristyn A BatesAlan R Harvey
Jul 29, 2006·Drugs & Aging·Paola SarchielliPaolo Calabresi
Mar 17, 2007·Free Radical Research·Rebecca WidmerTilman Grune
Mar 21, 2007·Brain, Behavior, and Immunity·J L TeelingV H Perry
May 12, 2007·Journal of the American Geriatrics Society·Snorri B RafnssonF Gerald R Fowkes
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Wolfgang J StreitEmalick Njie
Sep 9, 2008·Psychoneuroendocrinology·David GimenoArchana Singh-Manoux
Nov 29, 2008·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Gary W SmallMichael E Phelps
Feb 5, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Karthik BodhinathanThomas C Foster
Nov 9, 2010·Mechanisms of Ageing and Development·Zane ZeierThomas C Foster
Apr 20, 2011·Journal of Cellular Physiology·Takeshi KannoTomoyuki Nishizaki
Apr 24, 2012·Seminars in Cell & Developmental Biology·Ting-Ting HuangRikki Corniola
Oct 31, 2012·Brain, Behavior, and Immunity·Brandi K OrmerodTheo D Palmer
Jan 9, 2013·Neurobiology of Disease·Massimiliano Di FilippoPaolo Calabresi
Mar 16, 2013·Frontiers in Cellular Neuroscience·Wai T Wong
Oct 4, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ashok Kumar, Thomas C Foster
Mar 6, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael GuidiThomas C Foster
Sep 28, 2015·Behavioral and Brain Functions : BBF·Yuan YangJingjing Li

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