Feb 15, 1991

Nonsteroidal anti-inflammatory drug use and increased risk for peptic ulcer disease in elderly persons

Annals of Internal Medicine
Marie R GriffinWayne A Ray


To evaluate the relative risk for peptic ulcer disease that is associated with the use of nonaspirin nonsteroidal anti-inflammatory drugs. Nested case-control study. Tennessee Medicaid program. Medicaid enrollees 65 years of age or older were included in the study. The 1415 case patients had been hospitalized for confirmed peptic ulcer disease at some point from 1984 through 1986. The 7063 control persons represented a stratified random sample of other Medicaid enrollees. The estimated relative risk for the development of peptic ulcer disease among current users of nonaspirin nonsteroidal anti-inflammatory drugs, compared with that among nonusers, was 4.1 (95% CI, 3.5 to 4.7). For current users, the risk increased with increasing dose, from a relative risk of 2.8 (CI, 1.8 to 4.3) for the lowest to a relative risk of 8.0 (CI, 4.4 to 14.8) for the highest dose category. The risk was greatest in the first month of use (relative risk, 7.2; CI, 4.9 to 10.5). If the association is fully causal, 29% of peptic ulcers in the study sample resulted from the use of these drugs, and the excess risk associated with such use was 17.4 hospitalizations for ulcer disease per 1000 person-years of exposure. These data support other findings indica...Continue Reading

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Mentioned in this Paper

Peptic Ulcer
Marginal Ulcer
Analgesics, Anti-Inflammatory
Nonsteroidal Anti-inflammatory Drug [EPC]
Anti-Inflammatory Agents, Non-Steroidal
Alcohol Abuse
Odds Ratio
Nested Case-Control Studies
Regression Analysis

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