Nonsteroidal anti-inflammatory drug use in ankylosing spondylitis--a population-based survey

Clinical Rheumatology
Jane ZochlingJürgen Braun

Abstract

The objective of the study is to describe the use, clinical efficacy, and toxicity of nonsteroidal anti-inflammatory drug (NSAID) therapy in patients with ankylosing spondylitis (AS). A cross-sectional population study of 1,080 AS patients was carried out by a written questionnaire in the year 2000. Seventy-eight percent of AS patients had regularly taken NSAIDs for their disease 12 months prior to the study. Most AS patients commonly used diclofenac, naproxen and indomethacin. AS patients were generally rather satisfied with the efficacy of their therapy where 19.1% reported complete pain control, 26.8% reported pain reduction to one quarter, and a further 34.4% reported pain reduction to one half. However, over 20% of patients taking NSAIDs still reported insufficient pain control and more than 40% changed the NSAID due to lack of efficacy. One quarter of AS patients reported severe side effects from their treatment, most commonly abdominal pain, headache and dizziness, and nausea. There was no effect on age or duration of disease on the occurrence of NSAID-related side effects. Medications were commonly ceased or changed due to inefficacy or side effects. The percentage of AS patients reporting changing their NSAID due to si...Continue Reading

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Mar 3, 2007·Clinical Rheumatology·Liisa KonttinenUNKNOWN ROB-FIN Study Group
May 27, 2008·Wiener medizinische Wochenschrift·Sjef van der Linden
Jan 1, 2008·Core Evidence·Stephanie HenniganArthur Kavanaugh
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