Nonsteroidal anti-inflammatory drugs and necrotising fasciitis. An update

Drug Safety : an International Journal of Medical Toxicology and Drug Experience
E P HolderB A Browne

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen and others are the treatment of choice for mild to moderate pain. Because of the relative safety and efficacy of NSAIDs, many of the agents are now available in the US and in other parts of the world without a physician prescription. While these drugs are relatively well tolerated, adverse effects resulting from their use can occur. One such adverse effect recently linked to NSAID use is necrotising fasciitis. Reports of necrotising fasciitis possibly associated with NSAID use have been published in both the medical and lay literature. Several hypotheses regarding a possible association between NSAIDs and the development of necrotising fasciitis have appeared in the literature. One hypothesis is a simple masking of the signs and symptoms of an existing infection, leading to a delay in diagnosis. Some authors have speculated that in certain skin and soft-tissue infections, particularly those caused by group A beta-haemolytic streptococci, this delay in diagnosis may have allowed a simple infection to progress to necrotising fasciitis. Other postulated mechanisms of NSAID involvement in the development of necrotising fasciitis include an impairment of natur...Continue Reading

Citations

Nov 16, 2007·Archives of Gynecology and Obstetrics·Alejandro González CastroJosé Ramón de Miguel Sesmero
Aug 26, 1998·The American Journal of Medicine·D J Bjorkman
Sep 16, 1999·Biochemical Pharmacology·R LangenbachH Tiano
Apr 9, 2002·Prostaglandins & Other Lipid Mediators·Chatargy S KazaBasil Rigas
Sep 16, 2000·Journal of Pain and Symptom Management·C Hawkins, G W Hanks
Aug 7, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S Frick, A Cerny
Mar 17, 2001·Plastic and Reconstructive Surgery·T J AndreasenB J Childers
Oct 24, 2002·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·G VerfaillieL Corne
Apr 1, 2009·Critical Care : the Official Journal of the Critical Care Forum·Annick LegrasElisabeth Autret-Leca
May 26, 2006·International Wound Journal·Paul S Carter, Paul E Banwell
Nov 25, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·P K PrakashF W Hanna
Feb 12, 2008·Clinical and Experimental Dermatology·C SouyriUNKNOWN French Network of Pharmacovigilance Centres
Apr 3, 2014·Pediatric Pulmonology·Mohamed A ElemraidUNKNOWN North East of England Pediatric Respiratory Infection Study Group Newcastle upon Tyne, UK
Feb 25, 2010·Acta Paediatrica·Patrice FrançoisJosé Labarère
Oct 10, 2003·Journal of Wound Care·N Jallali

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.