Nonsteroidal anti-inflammatory drugs, aspirin, and cognitive function in the Baltimore longitudinal study of aging.

Journal of the American Geriatrics Society
Shari R WaldsteinAlan B Zonderman

Abstract

To examine the relations between the use of nonaspirin, nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin and age-related change in multiple domains of cognitive function in community-dwelling individuals without dementia. Longitudinal, with measures obtained on one to 18 occasions over up to 45 years. General community. A volunteer sample of up to 2,300 participants from the Baltimore Longitudinal Study of Aging free of diagnosed dementia. At each visit, reported NSAID or aspirin use (yes/no) and tests of verbal and visual memory, attention, perceptuo-motor speed, confrontation naming, executive function, and mental status. Mixed-effects regression models revealed that NSAID use was associated with less prospective decline on the Blessed Information-Memory-Concentration (I-M-C) Test, a mental status test weighted for memory and concentration (P<.001), and Part B of the Trail Making Test, a test of perceptuo-motor speed and mental flexibility (P<.05). In contrast, aspirin use was related to greater prospective decline on the Blessed I-M-C Test (P<.05) and the Benton Visual Retention Test, a test of visual memory (P<.001). Consistent with studies of incident dementia, NSAID users without dementia displayed less prospecti...Continue Reading

References

Apr 1, 1996·American Journal of Epidemiology·T StürmerC H Hennekens
Sep 1, 1996·Journal of the American Geriatrics Society·R RozziniJ M Guralnik
Mar 1, 1997·Neurology·W F StewartE J Metter
Oct 6, 1997·International Journal of Geriatric Psychiatry·A S HendersonA E Korten
Nov 14, 2000·Archives of Neurology·G A BroeG M Halliday
Jan 10, 2002·Journal of Clinical and Experimental Neuropsychology·L K LangleyJ B Overmier
Jan 17, 2002·The New England Journal of Medicine·B A in t' VeldB H Stricker
Sep 26, 2002·Neurology·Peter P ZandiUNKNOWN Cache County Study Investigators
Jun 27, 2003·European Journal of Clinical Pharmacology·Sven E NilssonArne Melander
Mar 1, 1995·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·A B ZondermanC H Kawas
Dec 16, 2004·JAMA : the Journal of the American Medical Association·Kenneth M LangaEric B Larson
May 1, 2007·BMJ : British Medical Journal·Jae Hee KangFrancine Grodstein
Jul 20, 2007·Neurology·K M HaydenUNKNOWN Cache County Investigators
Jan 19, 2008·BMJ : British Medical Journal·George KrasopoulosMichael R Buchanan

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Citations

Jul 23, 2011·Stroke; a Journal of Cerebral Circulation·Philip B GorelickUNKNOWN American Heart Association Stroke Council, Council on Epidemiology and Prevention, Council on Cardiovascular Nursing, Counci
Oct 8, 2013·Journal of Health Communication·Shwetha S SequeiraMichael K Paasche-Orlow
May 2, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Sharlène CôtéDanielle Laurin
Jul 16, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Stefano TarantiniPeter Toth
Jul 16, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·UNKNOWN ADAPT-FS Research Group
Jun 14, 2016·Expert Review of Neurotherapeutics·William James Deardorff, George T Grossberg
Aug 21, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Karen R ObermannCatherine M Roe
Jun 15, 2019·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Xiaoying CaiYannan Fang
Feb 25, 2020·BioMed Research International·Ya-Hsu YangLing-Ju Huang
Oct 1, 2011·Dementia & Neuropsychologia·Sonia Maria Dozzi BruckiUNKNOWN Working Group on Alzheimer's Disease and Vascular Dementia of the Brazilian Academy of Neurology
Jun 17, 2021·PloS One·Jinyan WengUNKNOWN Alzheimer’s Disease Neuroimaging Initiative

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