Nonsteroidal anti-inflammatory drugs-exacerbated respiratory disease in adolescents

International Forum of Allergy & Rhinology
Hacer Ilbilge Ertoy KaragolArzu Bakirtas

Abstract

There has been no study investigating nonsteroidal anti-inflammatory drugs (NSAIDs)-exacerbated respiratory disease (NERD) exclusively in childhood. Therefore, in the current study, the authors aimed to evaluate the diagnostic features, clinical characteristics, and follow-up of adolescents diagnosed with NERD. The patients who were consecutively diagnosed with NERD between January 2011, and November 2013, included in the study. Oral provocation test (OPT) with at least 2 different NSAIDs was used to confirm NSAID hypersensitivity in patients with underlying asthma/chronic rhinosinusitis/nasal polyps. All patients were followed regularly in 3-month intervals by the Pediatric Allergy and Otorhinolaryngology Department for asthma, allergic rhinitis, or chronic rhinosinusitis with or without nasal polyps. A total of 10 adolescents with NERD were included in the study. The mean age of the patients at the time of diagnosis was 14.9 ± 1.5 years. Hives or angioedema accompanied respiratory complaints induced by NSAIDs. The mean duration of follow-up was 28.9 ± 12.4 months. All patients had asthma except 1 with asymptomatic bronchial hyperreactivity. Asthma of patients was well-controlled with moderate dose of inhaled corticosteroids. ...Continue Reading

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Citations

May 12, 2015·International Forum of Allergy & Rhinology·Joseph Jacobs
Jul 10, 2016·The Journal of Allergy and Clinical Immunology. in Practice·Katherine L TuttleTanya M Laidlaw
Apr 26, 2018·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Mona KidonMarina Atanaskovic-Markovic
Sep 9, 2018·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ozlem CavkaytarDavide Caimmi
Aug 31, 2019·Pediatric Clinics of North America·Shazia Lutfeali, David A Khan

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