Nonsteroidal anti-inflammatory drugs (NSAIDs) in the newborn - which ones?

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Jacob V ArandaGloria B Valencia

Abstract

To determine which nonsteroidal anti-inflammatory drugs (NSAIDs) are being used in newborns. NSAID use was examined in local neonatal units and in published literature indexed by PubMed. Various NSAIDs are being used in newborns. Indomethacin and ibuprofen are used worldwide for closure of patent ductus arteriosus (PDA). Both have been tested in randomized clinical trials and are approved by FDA and EMEA for PDA closure in newborns. Indomethacin, but not ibuprofen is used for prevention of intraventricular hemorrhage (IVH). Ketorolac is being studied as a potential parenteral analgesic and as a topical drug for prevention of oxygen-induced retinopathy. Others are associated with severe adverse events. NSAIDs remain as active drugs used for PDA closure and IVH prevention. Potential uses including analgesia and retinopathy prevention are currently being studied.

References

Sep 2, 1976·The New England Journal of Medicine·M A HeymannN H Silverman
Aug 1, 1994·Acta Paediatrica Japonica; Overseas Edition·K ItoM Umetsu
Aug 1, 1997·Journal of Paediatrics and Child Health·P C NgW Wong
Sep 7, 2000·The New England Journal of Medicine·B Van OvermeireJ P Langhendries
May 22, 2004·Paediatric Anaesthesia·Patrizia PapacciCostantino Romagnoli
Aug 10, 2004·BMC Pediatrics·Medardo Avila-VazquezEduardo Bergel
Feb 18, 2005·European Journal of Pediatrics·Ronald L ThomasJacob V Aranda
Jul 4, 2006·Seminars in Perinatology·J V Aranda, Ronald Thomas
Jan 13, 2009·Cardiology in the Young·Tamara N DawkinsCatherine D Krawczeski
Mar 21, 2009·American Journal of Therapeutics·Athena F ZuppaDavid Cohen

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